2020年4月20日 · Perisciatic nerve administration of l-CDL suppressed the expression of NGF in the DRG and sciatic nerve of CCI rats. NGF plays a vital role in neuropathic pain, and the high level of NGF in the periphery accelerates the development of peripheral sensitization and sympathetic budding .

NGF antibodies and small-molecule inhibitors of NGF or the related receptors have been developed for the treatment of neuropathic pain. This review summarized the mechanisms of NGF’s...

CCI大鼠术后第6天在立体定位仪下侧脑室分别注射NGF抗体、PBS及对照抗体,测定MWT和TWL后处死并取触液核进行Western Blot观察p-ERK的表达变化情况。...

1999年2月1日 · In our study, we looked at the effects to the ligated nerves after 30 consecutive days of local injections of anti-NGF and NGF. A high-dose of anti-NGF (1800 ng) was found to eradicate heat and cold hyperalgesia during postoperative days 16–28 and from days 8 to 34 after CCI, respectively.

2020年4月20日 · In CCI rats, macropahages and Schwann cells could secret NGF to act on the receptors in the periphery to activate TAK1-MAPK/NF-κB axis and promote the release of proinflammatory cytokines, including TNF-α and IL-1β to promote neuropathic pain. l-CDL decreased the secretion of NGF through inhibiting AP-1 …

在坐骨神经慢性压迫损伤（chronic instruction injury，CCI） [1]、脊神经结扎（spinal nerve ligation，SNL） [2]、紫杉醇 [3]等诱导的神经病理性疼痛动物模型中NGF蛋白水平异常升高，临床神经病理性疼痛患者 [4]NGF表达上调。 其中，在CCI诱导的神经病理性疼痛模型中术侧坐骨神经 [5]、背根神经节（dorsal root ganglion，DRG） [6]、脊髓背角 [7]NGF蛋白或转录水平均显著增高。 足底注射NGF可剂量依赖性诱发大鼠热痛过敏和机械痛超敏，其中热痛过敏可持续24 h， …

The systemic administration of anti-nerve growth factor (NGF) antibodies can prevent local sensory hypersensitivity and block nociceptive fibers from sprouting into denervated adult rat skin. However, in the case of chronic constriction injury (CCI) in a rat, there is evidence that NGF reverses some …

We examined the effectiveness of anti-NGF in reducing chronic pain by local administration in a rat model of sciatic constriction injury (CCI). NGF and substance P in the dorsal root ganglion (DRG) and spinal cord were evaluated. Neuronal activation was measured using c-Fos in the anterior cingulate cortex and ventrolateral periaqueductal gray.

2020年9月27日 · 摘要： 目的:观察神经生长因子(nerve growth factor,NGF)在坐骨神经慢性压迫性损伤(chronic con-striction injury,CCI)大鼠触液核的表达以及拮抗触液核NGF对CCI大鼠痛行为学和触液核p-ERK表达的影响.方法:侧脑室注射CB-HRP逆行示踪触液核,结合免疫荧光双标观察正常大 …

2020年4月20日 · Perisciatic nerve administration of l-CDL suppressed the expression of NGF in the DRG and sciatic nerve of CCI rats. NGF plays a vital role in neuropathic pain, and the high level of NGF in the periphery accelerates the development of peripheral sensitization and sympathetic budding .