CCL17 is a powerful chemokine produced in the thymus and by antigen-presenting cells like dendritic cells, macrophages, and monocytes. [5] CCL17 plays a complex role in cancer. It attracts T-regulatory cells allowing for some cancers to evade an immune response. [ 6 ]

2024年4月17日 · 其中，CCL17（也称为TARC）作为一种新的人类CC趋化因子，近年来在生物医学研究中备受关注。 本文将深入探讨CCL17的基本概念、生物功能、在免疫系统中的作用，以及相关的研究进展和临床应用前景。 首先，让我们来了解一下CCL17的基本概念。 CCL17属于C-C趋化因子家族的成员，是一个碱性的94氨基酸残基前体蛋白，通过剪切产生一个71氨基酸残基成熟分泌蛋白。 它主要在胸腺中高水平表达，同时在肺、结肠和小肠中也有低水平表达。 在受刺激 …

CCL17, also known as thymic and activating regulatory chemokine (TARC), is a powerful chemokine commonly associated with type 2 immune responses, and its encoding gene is located on chromosome 16 in humans.

2024年12月24日 · CCL17 (C-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CCL17 include Eosinophilic Pneumonia and Paragonimiasis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

趋化因子受体(chemokine receptor，CCR)4是CCL17的高亲和力受体，是具有7个跨膜片段的G-蛋白耦联受体。CCL17具有多种生物学功能，参与到炎症、超敏反应、皮肤黏膜疾病、肿瘤、自身免疫性疾病等多个病理生理过程。

In this review, we summarize the biology of CCL17, its regulation and its potential contribution to the pathogenesis of various preclinical models. Reference is made, for example, to recent literature indicating a role for CCL17 in the control of pain as part of a granulocyte macrophage-colony-stimulating factor/CCL17 pathway in lymphocyte ...

Natural α-spinasterol is well known for its various biological activities. In this study, we investigated the anti-inflammatory effects of newly synthesized α-spinasterol derivatives by tracking the expression of CCL17 and CCL22 chemokines, which serve as biomarkers for immune cell trafficking in skin inflammation.

2023年4月19日 · Ccl17 knockout inhibited aging-induced vascular dysfunction. The aortas of young (4-month) and aged (21-month) WT and Ccl17 knockout (Ccl17-KO) male C57BL/6 mice were analyzed.

2023年3月28日 · CCL17 is elevated in many autoimmune/inflammatory diseases. CCL17, via its cognate receptor, CCR4, is traditionally viewed as a T-cell chemokine with its putative role mainly associated around Th2-driven pathology (e.g. atopic dermatitis and asthma) and Treg-driven pathology (e.g. Hodgkin's lymphoma and cancer metastasis). Recent studies have ...

2024年5月29日 · CCL17是CC趋化因子家族的小分子量细胞因子，在胸腺高表达，参与免疫平衡和中枢神经系统免疫细胞激活。 它可诱导T细胞趋化，在2型免疫反应和嗜酸性粒细胞相关疾病中起重要作用，还可能参与肿瘤细胞运输，并维持海马小胶质细胞形态。 趋化因子配体17（CCL17）也被称为胸腺活化调节趋化因子（TARC），是CC趋化因子家族的小分子量细胞因子。 CCL17的编码基因在人类中位于第16号染色体上，它与趋化因子受体CCR4相互作用，在调节免疫平衡和 …