Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family. The functions of CCL18 have been well studied in laboratory settings, however the physiological effects of the molecule in living organisms have been difficult to characterize because there is no similar protein in rodents that can be studied. The ...

2024年12月24日 · CCL18 (C-C Motif Chemokine Ligand 18) is a Protein Coding gene. Diseases associated with CCL18 include Gaucher's Disease and Septic Arthritis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include chemokine activity.

CCL18，又称巨噬细胞炎症蛋白-4 (MIP-4)，肺和激活调节趋化因子 (PARC)、树突状细胞 (DC)-趋化因子 1 (DC-CK1) 和替代巨噬细胞激活相关 CC 趋化因子-1 (AMAC-1)，是一种 CC 趋化因子家族的小细胞因子。 CCL18 在人类基因中位于 17 号染色体上，与 CCL3 具有最多的氨基酸同一性 (65%)，编码长为 89 个氨基酸的蛋白质，在 N' 末端还有一个 20 个氨基酸长的肽信号序列，可以发出其分泌信号，在内质网中被切割成一个 69 个氨基酸长的成熟蛋白质 [1]。 CCL18 主要由先 …

CCL18 overexpression predicts a worse prognosis in oral squamous cell carcinoma (OSCC). CCL18 is specific for disease activity in LoS thereby providing relevance as a biomarker for this debilitating disease. CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH-NF-kappaB signaling pathway.

c–c 基序趋化因子配体 18 (ccl18) 是一种在灵长类动物中具有免疫调节功能的 β-趋化因子亚家族成员。 口腔鳞状细胞癌、头颈部鳞状细胞癌、乳腺癌、肝细胞癌、非小细胞肺癌、卵巢癌、胰腺导管癌和膀胱癌细胞的 CCL18 依赖性迁移和上皮间质转化良好-已确立的。

2022年11月22日 · Blocking CCL18 by administration of anti-CCL18 neutralizing antibody could inhibit the formation of CD10 + GPR77 + CAFs in vivo, and recover the chemosensitivity, leading to effective tumor ...

CC chemokine ligand 18 (CCL18) was originally discovered as pulmonary and activation-regulated chemokine (PARC), dendritic cell (DC)-chemokine 1 (DC-CK1), alternative macrophage activation-associated CC chemokine-1 (AMAC-1), and macrophage ...

2019年4月12日 · Our data showed a significant increase in plasma levels of CCL18 in HIV-1-infected individuals compared to uninfected controls (p < 0.001) and a significant correlation between CCL18 levels and...

2021年8月1日 · CCL18 is a primate-specific chemokine produced by macrophages and dendritic cells. This chemokine presents both constitutive and inducible expression. It is mainly associated with a tolerogenic response and involved in maintaining homeostasis of the immune system under physiological conditions.

CCL18 induces regulatory phenotype and function of immune cells through direct activation and plays a major role in fibrotic processes, particularly in the lung. Finally, CCL18 is involved in cancer cell activation and migration and also participates in immune tolerance toward cancer.