2024年5月14日 · 趋化因子 (chemokine)是能够趋化细胞定向移动的小分子细胞因子,自1988年ValenteAJ等发现第一个趋化因子CCL2 (MCP21)以来,趋化因子及其受体的结构、功能及在体内的作用已经成为众多学者研究的热点。 趋化因子及其受体的相互作用参与细胞的生长、发育、分化、凋亡和分布等多种生理功能,并在多种病理过程中发挥重要作用,如炎症反应、病原体感染、创伤修复及肿瘤形成和转移等。 结构. 属于趋化因子的蛋白质不仅因为他们能够趋化吸引细胞，而且 …

2003年2月1日 · Using immunocytochemistry and in situ hybridization, CCL2 expression has been demonstrated within active and chronic active lesions in MS. Hypertrophic astrocytes and, to a lesser extent, mononuclear inflammatory cells were identified as the cellular source of CCL2 within active lesions, whereas hypertrophic astrocytes alone were associated ...

CCL2是趋化因子CC亚家族 (又称β亚家族)成员之一，即单核细胞趋化蛋白-1 (monocyte chemotactic protein-1，MCP-1)，可以趋化单核细胞、巨噬细胞和T淋巴细胞，影响其吞噬作用以及产生抗体，从而对抗外来入侵微生物的生理功能。 由于CCL2作用广泛，在体内各个部位均有一定表达，因此在近年来的研究中发现CCL2在肿瘤、中枢神经系统疾病、免疫系统疾病、艾滋病、白血病、糖尿病等诸多疾病的发生发展中起到了关键性的作用，该文就CCL2及其相关疾病的 …

研究表明，CCL2促进破骨细胞前体细胞的迁移，促进破骨细胞的发生和骨吸收。 CCL2和CCR2基因变异是 骨质疏松症 的危险因素。 CCL2在骨质疏松性骨和前列腺癌引起的骨吸收中有广泛表达。 成骨细胞CCL2的时空表达与炎症过程中单核细胞的募集和发育调控骨重建有关。 外源性CCL2可增强炎症骨中单核细胞的募集。 CCR2基因缺失小鼠的骨量较高，破骨细胞数量、大小和活性降低。 甲状旁腺激素（PTH）对骨骼有多方面的影响。 CCL2对甲状旁腺素的合成代谢和分解代谢作 …

Expression and cellular localization of CCL2/MCP-1 and CCR2 in MS have been described in the three compartments: brain, cerebrospinal fluid (CSF) and blood. Evidence from descriptive, transgenic, knockout and neutralizing studies of experimental autoimmune encephalomyelitis (EAE) points towards a nonredundant role of CCL2 and CCR2 in the ...

2021年1月6日 · Inflammatory chemokines that act as chemoattractants for monocytes and T cells have been shown to contribute in the pathogenesis of MS. Levels of these chemokines have been changed in the peripheral blood, CSF or demyelinating plaques of patients with MS. For instance, CCL2 levels have been shown to be diminished in the CSF of patients with MS ...

2023年12月1日 · The concentration of CCL2, CLL5, and CXCL10 are elevated in MS, and increase more with longer disease duration. Thus, the level of chemokines and any mutation in their DNA sequence may play a significant role in the pathogenesis of MS.

2013年6月15日 · Chemokine CCL2, a member of the monocyte chemoattractant protein (MCP) family, and its receptor CCR2 have been implicated in many neurodegenerative disorders. With respect to chronic neuroinflammation, a critical role for …

The chemokine monocyte chemoattractant protein (MCP)-1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), whereas data on the CCL2-CCR2 axis are scarce in MS. We studied the expres …

Chemokines are small cytokines with selective chemoattractant properties. They contribute to the T-cell-mediated pathogenesis of multiple sclerosis (MS). In order to ascertain whether different types and stage of disease correlate with a varying level of chemokines, the levels of CXCL8, CCL2 and CCL …