2020年2月14日 · Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is a potent cytokine involved in the recruitment...

We identify that BM-MSC-secreted chemokine ligand 2 (CCL2) and C-X-C motif chemokine 12 (CXCL12) cooperate as a heterodimer to upregulate IL-10 expression in CCR2 + macrophages in vitro and that CCL2 expression by MSC is required for IL-10 + polarization of intestinal and peritoneal resident macrophages in vivo.

2020年2月11日 · We identify that BM-MSC-secreted chemokine ligand 2 (CCL2) and C-X-C motif chemokine 12 (CXCL12) cooperate as a heterodimer to upregulate IL-10 expression in CCR2 + macrophages in vitro and that CCL2 expression by MSC is required for IL-10 + polarization of intestinal and peritoneal resident macrophages in vivo. We observe that tissue ...

2021年4月20日 · In SLE patients, decreased expression of CCL2 on mesenchymal stem cells (MSC) prevents inhibition of B-cell proliferation, causing the characteristic autoimmune phenotype. Nevertheless, the...

2021年9月13日 · 7月，北大医院血液内科任汉云教授、李渊副教授团队研究发现骨髓来源间充质干细胞（Mesenchymal stem cells，MSCs）可通过调节趋化因子CCR2-CCL2轴抑制T细胞活化，诱导具有免疫调节作用的CCR2+CD4+T细胞生成，进而达到预防小鼠异基因造血干细胞移植后特发 …

2022年11月26日 · We found that MSCs-IT significantly alleviated skin fibrosis during SSc by reducing the infiltration of pathogenic CCR2 hi macrophages. MSC-IT treatment reduced the generation of CCL2 from...

2020年2月14日 · Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is a potent cytokine involved in the recruitment of macrophages. We hypothesised that MSC derived CCL2 may be involved in the MSC therapeutic effect by fac …

Single-cell RNA sequence analysis in human bone marrow cells confirms the significance of MSC-derived CCL2 in cell fate determination, providing valuable insights on the in vivo effects of MSC transplantation.

At four-weeks post-transplantation, the CCL2-MSC group showed significantly better functional recovery and smaller stroke volume relative to the other groups. Additionally, we observed upregulated levels of CCR2 in acute ischemic brain and the increase of migrated stem cells into these areas in the CCL2-MSC group relative to the M-MSC.

4 天之前 · Our findings demonstrate that the protective effect of MSC-MVs against BLM-induced lung toxicity was achieved through the inhibition of the ERK1/2 signaling pathway, leading to the suppression of CCL2 expression and subsequent modulation of monocyte-macrophage migration, thereby establishing a theoretical basis for the effect of MSC-MVs in PF.