2023年9月1日 · Somatic mutations in MAP3K3 and PIK3CA were recently reported in patients with sporadic CCM, yet it remains unknown whether MAP3K3 mutation is sufficient to induce …

与ccm1/2/3和pik3ca诱导的ccm不同，map3k3 i441m 突变在散发性脑和脊髓海绵状血管畸形患者队列中被广泛发现，这强烈表明，一次打击机制可能是ccm形成的基础，我们的ccm小鼠模型 …

2021年5月6日 · Leveraging mini-bulk sequencing, we demonstrate the enrichment of MAP3K3 c.1323C>G mutation in CCM endothelium. Mechanistically, beyond the activation of CCM1/2/3 …

2021年5月6日 · Leveraging mini-bulk sequencing, we demonstrate the enrichment of MAP3K3 c.1323C>G mutation in CCM endothelium. Mechanistically, beyond the activation of CCM1/2/3 …

2 天之前 · The Map3k3 I441M knock-in mice were crossed with Cdh5-creER T2 mice to induce mutant gene expression specifically in endothelial cells. Subsequently, Map3k3 I441M mice …

该论文提供了迄今为止最为完整的脑海绵状血管畸形（cerebral cavernous malformation, CCM）包括CCM基因突变、MAP3K3、 PIK3CA、 MAP2K7等体细胞基因突变的基因突变全景图。

2023年1月31日 · By using AAV-BR1, we found that MAP3K3I441M mutation can provoke CCM-like lesions in mice and the activation of PI3K signaling significantly enhances and maintains …

2021年7月5日 · 该论文提供了迄今为止最为完整的脑海绵状血管畸形（cerebral cavernous malformation, CCM）基因突变全景图——单纯性CCM存在CCM 1/2、MAP3K3、 PIK3CA、 …

By using AAV-BR1, we found that MAP3K3 I441M mutation can provoke CCM-like lesions in mice and the activation of PI3K signaling significantly enhances and maintains these lesions, …

Somatic mutations in MAP3K3 and PIK3CA were recently reported in patients with sporadic CCM, yet it remains unknown whether MAP3K3 mutation is sufficient to induce CCMs. Here we …