2024年12月24日 · CCNB1 (Cyclin B1) is a Protein Coding gene. Diseases associated with CCNB1 include Laryngeal Squamous Cell Carcinoma and Retinoblastoma . Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Mitotic G1 phase and G1/S transition .

G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. [5] Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34 (Cdk1) to form the maturation-promoting factor (MPF).

CCNB1 was knocked-down by lentiviral-mediated infection of short hairpin RNA (shRNA) in GH3 and MMQ cell lines. The proliferation, cell cycle and apoptosis of GH3 and MMQ cell lines were detected using a Cell Counting Kit-8 and flow cytometer.

2025年2月8日 · CCNB1 is a biomarker for the prognosis of ER+ breast cancer and monitoring of hormone therapy efficacy that CCNB1 contained many CD4 T cell epitopes, which are differentially recognized by pre-existing naive and memory CD4 T cells.

2023年8月17日 · CCNB1 silencing significantly inhibited the proliferation, migration, and invasive capabilities of WIT-49 cells, also, promoted apoptosis, and in turn induced G2 phase cell cycle arrest in loss-of-function assays.

CCNB1 is a key gene associated with LVI in BC and has prognostic value. More functional studies are warranted to unravel the mechanistic role of CCNB1 in the development of LVI. The online version contains supplementary material available at 10.1007/s10549-022-06801-2. Keywords: CCNB1, Breast cancer, Progression, LVI, Prognosis.

Kaplan–Meier survival analyses confirmed that elevated CDK1, CCNA2, and CCNB1 expression levels were associated with overall and post-progression survival and recurrence-free probability rates in patients with BRCA.

2023年9月27日 · We comprehensively evaluated the expression and promoter methylation of CCNB1 across 38 cancers based on RNA sequencing data obtained from the Cancer Genome Atlas (TCGA). The correlation of...

2020年8月31日 · We aimed to comprehensively investigate the roles of CDK1, CCNB1, and CCNB2 via multi-omics analysis and their relationships with immune infiltration in hepatocellular carcinoma (HCC).

2022年9月27日 · After enrichment, survival analysis, one potential gene, Cyclin B1 (CCNB1), was selected for further expression verification at the mRNA and protein level. Taker together, CCNB1 may act as a...