Anti-CCP2 and anti-CCP3 assays show equivalent diagnostic performance in early RA patients when adjusted for high specificity. Determination of IgA anti-citrullinated protein antibodies might provide additional prognostic information with respect to therapeutic responses.

Comparisons of CCP2 and CCP3.1 assays have shown increased sensitivity, but decreased specificity of CCP3.1 compared to CCP2 [26,27], but little is known about the direct comparison between the third generation IgG assays (CCP3) and the IgG/IgA combination assay (CCP3.1). Therefore, the objective of this work is to compare the performance of ...

2012年12月24日 · A comparison of the frequency of antibodies to cyclic citrullinated peptides using a third generation anti-CCP assay (CCP3) in systemic sclerosis, primary biliary cirrhosis and rheumatoid arthritis

The anti-CCP3.1 assay marketed by INOVA detects both IgG and IgA CCP3 antibodies in an effort to increase sensitivity . Eurodiagnostica has developed a “point-of-care” assay, employing a finger lancet to obtain a drop of blood for rapid office-based results.

Anti-cyclic citrullinated peptide antibodies (anti-CCPs) are important diagnostic markers for rheumatoid arthritis (RA). We evaluated the analytical and clinical performance of the QUANTA Flash CCP3 (INOVA Diagnostics, USA), a fully automated third-generation anti-CCP assay, in comparison with three …

In this study, we wished to assess the diagnostic performance of the third-generation anti-CCP3.1 assay, but with special focus on the rheumatoid factor (RF)-negative RA population. Anti-CCP as well as anti-MCV was tested in 119 RA patients and 118 control patients using second and third-generation assays.

This study compares the diagnostic performance of a second generation anti-cyclic citrullinated peptide antibody (CCP2) with a third generation anti-CCP antibodies assay (CCP3), as well as the combination of both tests.

2007年11月1日 · The aims of the present study were to compare the diagnostic and clinical value of seven commercially available assays for second-generation anti-cyclic citrullinated peptide (CCP2) antibodies, anti-keratin antibodies (AKA) and rheumatoid factor (RF) determination in patients with rheumatoid arthritis (RA), and to check the potential advantages ...

2024年8月1日 · In clinical practice ACPA can be identified using immunoassays targeting synthetic cyclic citrullinated peptides (CCP). The 3rd generation anti-CCP IgG antibody (CCP3) offers improved sensitivity compared to the earlier versions.

2023年8月21日 · Highly specific serologic test to aid in the workup of suspected rheumatoid arthritis (RA) or undifferentiated inflammatory arthritides. Use of IgA and IgG antibodies against cyclic citrullinated peptide (CCP) enhances sensitivity for RA diagnosis. The preferred test for initial screening is Rheumatoid Arthritis (RA) Panel (3016634).