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Wikipedia
https://en.wikipedia.org › wiki
C-C chemokine receptor type 6 - Wikipedia
Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. CCR6 has also recently been designated CD196 (cluster of differentiation 196). The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids (molecular weight 42,49…
Function
This protein belongs to family A of G protein-coupled receptor superfamily. The gene is expressed in lymphatic … 展开
Clinical significance
CCR6 has a function in development and metastatic spread of gastrointestinal malignancies. Expression of CCR6 was found to be up-regulated in colorectal cancer. Many patients with colorectal cancer have live… 展开
External links
• Human CCR6 genome location and CCR6 gene details page in the UCSC Genome Browser.
• "Chemokine Receptors: CCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmac… 展开
靶向免疫治疗“黄金搭档”——趋化因子CCR家族 - 知乎
本文介绍了趋化因子CCR家族的结构、功能和信号通路，以及针对CCR家族的靶向免疫治疗药物的开发和临床应用。文章还提供了BioMice百奥动物自主开发的CCR家族靶点人源化小鼠的基本信息和蛋白表达分析结果。
知乎专栏
CCR6 Gene - GeneCards | CCR6 Protein | CCR6 Antibody
CCR6 is a gene that encodes a receptor for chemokines and defensins, involved in i…
GeneCards
CC-BY-SA 许可证中的维基百科文本

知乎专栏
https://zhuanlan.zhihu.com
CCR6：“专一性”趋化因子受体，炎症性和消化系统肿瘤 …
2024年3月12日 · CCR6是一种G蛋白偶联趋化因子受体，与CCL20紧密结合形成一对具有高度亲和力和“专一性”的趋化因子受配体。CCR6在炎症性疾病、自身免疫疾病和消化系统肿瘤中发挥重要作用，是一种有望成为靶向药物研发的潜力 …
知乎专栏
https://zhuanlan.zhihu.com
靶向免疫治疗“黄金搭档”——趋化因子CCR家族 - 知乎
本文介绍了趋化因子CCR家族的结构、功能和信号通路，以及针对CCR家族的靶向免疫治疗药物的开发和临床应用。文章还提供了BioMice百奥动物自主开发的CCR家族靶点人源化小鼠的基本 …
GeneCards
https://www.genecards.org › cgi-bin › car…
CCR6 Gene - GeneCards | CCR6 Protein | CCR6 Antibody
2024年12月24日 · CCR6 is a gene that encodes a receptor for chemokines and defensins, involved in immune cell migration and function. Learn about its aliases, disorders, pathways, products, antibodies, and more from GeneCards database.
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
CCR6 C-C motif chemokine receptor 6 [ (human)] - National …
CCR6 defines memory B cell precursors in mouse and human germinal centers, revealing light-zone location and predominant low antigen affinity. High expression of CCR6 is associated …

PubMed
https://pubmed.ncbi.nlm.nih.gov
CCR6 as a Potential Target for Therapeutic Antibodies for the
2023年4月20日 · The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes. When CCR6 binds to its sole ligand CCL20, …
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Where is CCR6 expressed?
CCR6 is expressed on B-cells, immature dendritic cells (DC), T-cells (Th1, Th2, Th17, Treg), natural killer T cells (NKT cells) and neutrophils. The ligand of this receptor is CCL20 or in the other name - macrophage inflammatory protein 3 alpha (MIP-3 alpha).
C-C chemokine receptor type 6 - Wikipedia
en.wikipedia.org
What is CC chemokine receptor 6?
The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling network is produced. This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multipl …
CCR6 as a Potential Target for Therapeutic Antibodies for the ... - PubM…
pubmed.ncbi.nlm.nih.gov
Why is CCR6 important?
CCR6 has a key role between immature DC and adaptive immunity. This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic cells and T cells during inflammatory and immunological responses.
C-C chemokine receptor type 6 - Wikipedia
en.wikipedia.org
Is CCR6 a protein coding gene?
Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] CCR6 (C-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CCR6 include Diffuse Cutaneous Systemic Sclerosis and Limited Scleroderma.
CCR6 Gene - GeneCards | CCR6 Protein | CCR6 Antibody
genecards.org
What diseases are associated with CCR6?
Diseases associated with CCR6 include Diffuse Cutaneous Systemic Sclerosis and Limited Scleroderma. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and chemokine receptor activity.
CCR6 Gene - GeneCards | CCR6 Protein | CCR6 Antibody
genecards.org
How does CCR6 affect cutaneous T-cell lymphoma?
CCR6 defines memory B cell precursors in mouse and human germinal centers, revealing light-zone location and predominant low antigen affinity. High expression of CCR6 is associated with cutaneous T-cell lymphoma. CCR6 (-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected patients.
CCR6 C-C motif chemokine receptor 6 [ (human)]
ncbi.nlm.nih.gov
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万方数据知识服务平台
https://d.wanfangdata.com.cn › Periodical
CCR6及CCL20在相关疾病中的研究进展-期刊-万方数据知识服务平台
本文综述了CCR6及CCL20的结构、功能和在多种相关疾病中的作用机制，以及相关的临床意义和治疗策略。CCR6是一种表达于多种免疫细胞和肿瘤细胞的趋化因子受体，CCL20是其唯一的 …
百家号
https://baijiahao.baidu.com
CCR6重组蛋白：趋化因子C-C-基元受体6重组蛋白 - 百家号
CCR6重组蛋白是一种细胞因子受体蛋白，与CCL20配体结合调节细胞的趋化和激活，参与免疫和炎症反应。CCR6重组蛋白还与自身免疫性疾病和的发生和发展有关，对于理解疾病机制和治 …
Nature
https://www.nature.com › articles
Structural basis for chemokine receptor CCR6 activation by the ...
2020年6月15日 · CCR6 is a CC chemokine receptor that is selectively expressed in immature dendritic cells and memory T-cells 1. It primarily couples through G i/o proteins upon …
华美生物
https://www.cusabio.cn › research-hotsp…
CCR6：“专一性”趋化因子受体，炎症性和消化系统肿瘤 …
2024年1月12日 · CCR6是一种G蛋白偶联趋化因子受体，与CCL20紧密结合形成一对具有高度亲和力和“专一性”的趋化因子受配体。CCR6在炎症性疾病、自身免疫疾病和消化系统肿瘤中发挥重要作用，是一种有潜力的靶标。
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C-C chemokine receptor type 6 - Wikipedia

CCR6：“专一性”趋化因子受体，炎症性和消化系统肿瘤 …

靶向免疫治疗“黄金搭档”——趋化因子CCR家族 - 知乎

CCR6 Gene - GeneCards | CCR6 Protein | CCR6 Antibody

CCR6 C-C motif chemokine receptor 6 [ (human)] - National …

CCR6 as a Potential Target for Therapeutic Antibodies for the

C-C chemokine receptor type 6 - Wikipedia

CCR6 as a Potential Target for Therapeutic Antibodies for the ... - PubM…

C-C chemokine receptor type 6 - Wikipedia

CCR6 Gene - GeneCards | CCR6 Protein | CCR6 Antibody

CCR6 Gene - GeneCards | CCR6 Protein | CCR6 Antibody

CCR6 C-C motif chemokine receptor 6 [ (human)]

CCR6及CCL20在相关疾病中的研究进展-期刊-万方数据知识服务平台

CCR6重组蛋白：趋化因子C-C-基元受体6重组蛋白 - 百家号

Structural basis for chemokine receptor CCR6 activation by the ...

CCR6：“专一性”趋化因子受体，炎症性和消化系统肿瘤 …

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