005793 B6.129P2- Ccr6 tm1Dgen /J No significant phenotypic differences are detected in homozygous mutant animals when compared with age- and gender-matched wild-type control mice for this targeted mutant knock-out.

2023年1月22日 · In this study, we generated CCL20-KO and CCR6-KO mice with a C57BL/6 genetic background using the CRISPR/Cas9 system, examining the pathological scores and body weight loss of the mutant and wild-type mice, and using histopathological staining to investigate inflammatory cell infiltration and demyelination in the CNS.

To assess the CCR6 effect in inflammatory tissue, CCR6 KO and control C57BL/6 mice were immunized with MOG peptide with CFA to induce EAE. CCR6 KO mice exhibited significantly reduced EAE disease compared with C57BL/6 mice in the early phase of EAE.

We use CCR6-deficient (knockout, KO) and wild-type (WT) mice to analyze skin trafficking patterns of GDL T cells and function-blocking mAbs to determine the role of CCR6 in IL-23-mediated dermatitis. Herein, CCL20 was highly upregulated in IL-23-injected WT mouse ear skin as early as 24 hours after initial treatment, and large numbers of CCR6 ...

We generated C-C motif chemokine receptor 2 (CCR2) knockout (KO) and CCR6 KO mice in the syngeneic background using the CRISPR/Cas9 system and found that the phenotypes of experimental colitis worsened in both mutant mice.

2024年3月12日 · CCR6是一种 G蛋白偶联趋化因子受体，与CCL20紧密结合形成一对具有高度亲和力和“专一性”的趋化因子受配体。 大量研究表明，CCR6与多种炎症性疾病相关，并且在多种消化系统肿瘤的发生与发展中发挥重要作用。 CCR6作为一种独特的趋化因子受体，有望为未来的靶向药物研发提供新的策略。 今天，让我们深入了解这个“专一性”趋化因子受体CCR6！ 1. 什么是趋化因子家族？ 2. 什么是CCR6？ 3. 什么是CCR6的配体？ 4. CCR6相关的信号调控机制. 5. …

敲除Ccr6基因的exon 3 区域，获得Ccr6基因敲除小鼠模型。 应用领域 ：免疫相关 *使用本品系发表的文献需注明: Ccr6-KO mice (Cat. NO. NM-KO-190022) were purchased from Shanghai Model Organisms Center, Inc..

2024年7月16日 · Data accompanying the manuscript "The CCR6–CCL20 axis promotes regulatory T cell glycolysis and immunosuppression in tumors"-- includes RNA-Seq of sorted murine Tregs from WT and Ccr6 KO mice. The experiment was designed to compare transcriptomic differences between WT and Ccr6 KO Tregs during activation.

2021年12月6日 · 作者发现ccr6-ko小鼠可以提高骨转移小鼠的生存率。 CCL20阻断抗体作用于小鼠模型也能够达到一致的效果。 分析骨转移部位细胞发现，CCR6-KO小鼠中激活的Treg细胞以及耗竭CTL数量减少，幼稚CTL增加，骨髓腔中TAM细胞数明显减少，骨转移部位的免疫抑制微环境得 …

2009年3月22日 · Here we found that mice lacking CCR6, a chemokine receptor characteristic of TH-17 cells, developed TH-17 responses but were highly resistant to the induction of experimental autoimmune ...