2025年3月14日 · CCR8, like other chemokine receptors, is a GPCR with a seven-transmembrane (7TM) domain embedded in the cell membrane. This structure enables conformational changes upon ligand binding, facilitating intracellular signaling.

2024年2月2日 · The human CC chemokine receptor 8 (CCR8) is an emerging therapeutic target for cancer immunotherapy and autoimmune diseases. Understanding the molecular …

2016年7月29日 · To test the importance of the two disulfide bridges, the 7TM receptor conserved disulfide bridge (7TM bridge) and the chemokine receptor conserved disulfide bridge (CKR bridge) (Fig. 1A), for ligand binding to and activation of CCR8, each bridge was disrupted by substituting cysteine with alanine residues.

CCR8（Chemokine receptor 8） 是一种七跨膜G蛋白偶联受体，属于趋化因子受体C-C亚家族。 CCR8在Th2细胞、单核细胞和NK细胞上有表达，在Th1细胞上不表达。 此外，CCR8在Treg细胞中也有表达，在肿瘤浸润的Treg细胞中高表达，在胸腺、脾脏和外周血的Treg细胞中表达量较低。 CCR8通过与其配体的相互作用参与了多种肿瘤的发展进程以及介导了肿瘤的免疫。 肿瘤部位的Treg上的CCR8特异性高表达表明CCR8是肿瘤部位的Treg细胞的非常好的生物标志物，是极 …

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell Apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues.

2024年12月24日 · CCR8 (C-C Motif Chemokine Receptor 8) is a Protein Coding gene. Diseases associated with CCR8 include Molluscum Contagiosum and Kaposi Sarcoma. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

The Conserved Disulfide Bridges Are Important for Chemo-kine-mediated Activation of CCR8—To test the importance of the two disulfide bridges, the 7TM receptor conserved disulfide bridge (7TM bridge) and the chemokine receptor conserved disulfide bridge (CKR bridge) (Fig. 1A), for ligand binding to and activation of CCR8, each bridge was ...

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Was originally thought to be a receptor for SCYA3 and SCYA17. Gene Ontology (GO) annotations organized by slimming set. Cell membrane ; Multi-pass membrane protein.

CCR8 是 CC基序趋化因子受体 8（hemokine (C-C motif) receptor 8），作为一种在肿瘤浸润的调节性T细胞（Treg）上特异性高表达的趋化因子受体，其属于 G蛋白偶联受体。

2016年7月29日 · We find that the seven-transmembrane (TM) receptor conserved disulfide bridge (7TM bridge) linking transmembrane helix III (TMIII) and ECL-2 is crucial for chemokine and small molecule action, whereas the chemokine receptor conserved disulfide bridge between the N terminus and TMVII is needed only for chemokines.