CCR8: a promising therapeutic target against tumor-infiltrating ...
2025年1月30日 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a …
华中科技大学高庆蕾教授团队Trends in Immunology综述丨CCR8推 …
2025年3月16日 · 华中科技大学同济医学院附属同济医院高庆蕾教授团队在Cell Press细胞出版社旗下期刊Trends in Immunology发表了题为“CCR8: a promising therapeutic target against ...
CCR8: a promising therapeutic target against tumor-infiltrating ...
Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising …
The impact of CCR8+ regulatory T cells on cytotoxic T cell
2022年3月30日 · We found that gene related T cell and antigen-presenting cell (APC) were significantly reduced in CCR8-high tumors compared with levels in CCR8-low tumors in both …
Structural basis of antibody inhibition and chemokine activation of …
2023年12月1日 · Our studies reveal characteristic antibody features allowing recognition of the CCR8 extracellular loops and CCL1-CCR8 interaction modes that are distinct from other …
CCR8 marks highly suppressive Treg cells within tumours but is ...
High levels of expression of chemokine (C-C motif) receptor 8 (CCR8) discriminate Treg cells within tumours from those found in systemic lymphoid tissues. It has recently been proposed …
Immunotherapy Targeting CCR8+ Regulatory T Cells Induces …
2023年6月30日 · In this study, we analyzed changes to intratumor immunity after anti-CCR8 Ab administration, especially in CD8 + T cells, which are involved in cancer cell killing, using the …
Development of a cellular model to study CCR8 signaling in tumor ...
2024年1月17日 · It was unveiled in 2016 that CCR8 is specifically expressed on tumor-infiltrating regulatory T cells (TITRs) across a range of primary and metastatic human cancer types, …
Targeting tumor-infiltrating CCR8+ regulatory T cells induces …
2024年7月30日 · Chemokine (C-C motif) receptor 8 (CCR8) is a chemokine receptor selectively expressed on tumor-infiltrating regulatory T cells (Tregs). Strong immunosuppression …
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells ...
We generated two CCR8-specific nanobodies (Nbs) that recognize distinct epitopes on the CCR8 extracellular domain. These Nbs were formulated as tetravalent Nb-Fc fusion proteins for …
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