CCR8: a promising therapeutic target against tumor-infiltrating ...
2025年1月30日 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a …
S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent …
2023年9月5日 · To generate an anti-human CCR8 antibody suitable for cancer immunotherapy, we screened monoclonal anti-CCR8 IgG1 antibodies and found a novel anti-human CCR8 …
Selective depletion of tumor-infiltrating regulatory T cells with BAY ...
2024年6月10日 · In this study, as shown also by others, the chemokine (C–C motif) receptor 8 (CCR8) was found to be predominantly expressed on Tregs within the TME of both humans …
CCR8-targeted specific depletion of clonally expanded Treg cells …
With the anti-CCR8–treated mice having eradicated CT26 tumors by around day 20 after tumor inoculation, we challenged the mice with 10 times the number of CT26 or EMT6 carcinoma …
Chemokine Receptor-Targeted Therapies: Special Case for CCR8
2022年1月20日 · Preclinical studies in mice modelling colon (BC38, CT26), melanoma (B16F10), breast (EMT6) and urothelial (MB49) cancer revealed that tumor Treg cells expressed high …
CCR8 as a Therapeutic Novel Target: Omics-Integrated …
This analysis will encompass the correlations between CCR8 subunit expression levels and tumor immune infiltration levels (B cells, CD4 T cells, CD8 T cells, neutrophils, macrophages, and …
新兴免疫靶点CCR8图鉴 - 知乎 - 知乎专栏
IPG7236 是艾美斐生物自主研发的靶向CCR8的小分子抑制剂，它不仅能够抑制肿瘤细胞转移，也可以抑制肿瘤相关Treg细胞向肿瘤组织浸润，从而逆转肿瘤免疫抑制性微环境，增强抗肿瘤免 …
CCR8-targeted specific depletion of clonally expanded Treg
Representative data of two biological replicates. (C) CCR8 protein expression by CD3 + CD4 + T cells in LNs, DLNs, and tumors. CT26-, EMT6-, or Renca-bearing mice 18, 10, or 13 d, …
Science Advances｜徐菲课题组揭示肿瘤免疫明星靶点CCR8的配体 …
2024年2月3日 · 徐菲团队在国际学术期刊《科学进展》(Science Advances)上发表题为“Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human …
S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent …
In this study, we developed a novel humanized anti-human CCR8 antibody, S-531011, which has antibody-dependent cell-mediated cytotoxicity (ADCC) activity against tumor-infiltrating CCR8 …
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