Further analysis demonstrated that CCL1 activates the MAPK pathway in CCR8-transfected CHO cells. The implication of this pathway was confirmed by the fact that PD98059, an inhibitor of MEK kinases, as well as a dominant negative isoform of the M-RAS protein specifically blocked the anti-apoptotic activity of CCL1.

2025年2月1日 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

We show that CCL1 and vMIP-I induce ERK1/2 phosphorylation, that CCR8 stimulation activates the MAP-kinase path-way, and that the effect of CCL1 is blocked by an inhibi-tor of this pathway and by a dominant negative RAS iso-form, demonstrating the role of the RAS/MAP-kinase pathway in this anti-apoptotic activity.

2023年12月1日 · Nature Communications - CCR8 is a promising target in cancer immunotherapy. Here, authors generated mAb1, an antagonist antibody against CCR8 and determined structures of CCR8 in complex with...

We show that CCL1 and vMIP-I induce ERK1/2 phosphorylation, that CCR8 stimulation activates the MAP-kinase pathway, and that the effect of CCL1 is blocked by an inhibitor of this pathway and by a dominant negative RAS isoform, demonstrating the role of the RAS/MAP-kinase pathway in this anti-apoptotic activity.

Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand

2024年4月29日 · CC族趋化因子受体8（CC chemokine receptor 8，CCR8）属于CC族趋化因子受体家族，其主要在肿瘤微环境中的Treg细胞上特异性高表达，而在周围正常组织和外周血中低表达，因此CCR8可以作为Treg细胞的一种特异性标志物，是一种有潜力的治疗靶点和生物标志物。 本文对近年来CCR8在不同瘤种中的研究进展进行了归纳和总结，以期为后续研究提供参考。 [关键词] 肿瘤；CC族趋化因子受体8；免疫治疗；靶向治疗.

CCR8（Chemokine receptor 8） 是一种七跨膜G蛋白偶联受体，属于趋化因子受体C-C亚家族。 CCR8在Th2细胞、单核细胞和NK细胞上有表达，在Th1细胞上不表达。 此外，CCR8在Treg细胞中也有表达，在肿瘤浸润的Treg细胞中高表达，在胸腺、脾脏和外周血的Treg细胞中表达量较低。 CCR8通过与其配体的相互作用参与了多种肿瘤的发展进程以及介导了肿瘤的免疫。 肿瘤部位的Treg上的CCR8特异性高表达表明CCR8是肿瘤部位的Treg细胞的非常好的生物标志物，是极 …

2025年1月30日 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

2024年2月3日 · 徐菲团队在国际学术期刊《科学进展》(Science Advances)上发表题为“Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8”的研究论文，揭示了趋化因子受体CCR8识别非肽配体并激活的分子机制。