CCR8-targeted specific depletion of clonally expanded Treg cells …
2022年2月15日 · Administration of cell-depleting anti-CCR8 monoclonal antibodies (mAbs) indeed selectively eliminated multiclonal tumor Tregs, leading to cure of established tumors in mice. …
肿瘤免疫靶点｜CCR8 - 知乎 - 知乎专栏
肿瘤部位的Treg上的CCR8特异性高表达表明CCR8是肿瘤部位的Treg细胞的非常好的生物标志物，是极具潜力的肿瘤免疫靶点。 CCR8配体 人类CCR8有四种已知配体：CCL1、CCL8 …
The impact of CCR8+ regulatory T cells on cytotoxic T cell
2022年3月30日 · Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, …
CCR8 marks highly suppressive Treg cells within tumours but is ...
High levels of expression of chemokine (C-C motif) receptor 8 (CCR8) discriminate Treg cells within tumours from those found in systemic lymphoid tissues. It has recently been proposed …
华中科技大学高庆蕾教授团队Trends in Immunology综述丨CCR8推动肿瘤Treg …
2025年3月16日 · TI-Treg细胞中CCR8的高表达表明，抗CCR8药物能够有效靶向TI-Treg细胞，同时对Tconv和外周Treg细胞的影响较小。 抗CCR8药物在多种临床前模型中展示了良好 ...
Targeting tumor-infiltrating CCR8+ regulatory T cells induces …
2024年7月30日 · Chemokine (C-C motif) receptor 8 (CCR8) is a chemokine receptor selectively expressed on tumor-infiltrating regulatory T cells (Tregs). Strong immunosuppression …
CCR8: a promising therapeutic target against tumor-infiltrating ...
2025年2月1日 · CC chemokine receptor (CCR)8 has emerged as a promising therapeutic target against TI-Treg cells for its predominant expression on effector TI-Treg cells and minimal …
Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells …
2021年6月1日 · Preclinical mouse tumor modeling showed that depletion of CCR8 + Tregs through an FcyR-engaging anti-CCR8 antibody, but not blockade, enabled dose-dependent, …
Science Advances｜徐菲课题组揭示肿瘤免疫明星靶点CCR8的配体 …
2024年2月3日 · 徐菲团队在国际学术期刊《科学进展》(Science Advances)上发表题为“Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human …
CCR8+FOXp3+ Treg cells as master drivers of immune regulation
2017年5月22日 · The current study identifies CCR8 + regulatory T cells (T reg cells) as drivers of immunosuppression and provides compelling evidence of a self-feeding mechanism by which, …