We generated two CCR8-specific nanobodies (Nbs) that recognize distinct epitopes on the CCR8 extracellular domain. These Nbs were formulated as tetravalent Nb-Fc fusion proteins for optimal CCR8 binding and blocking, containing either an antibody-dependent cell-mediated cytotoxicity (ADCC)-deficient or an ADCC-prone Fc region.

Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

2025年3月16日 · Van Damme, H. et al. (2021) Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy. J. Immunother. Cancer 9, e001749

CCR8（Chemokine receptor 8） 是一种七跨膜G蛋白偶联受体，属于趋化因子受体C-C亚家族。 CCR8在Th2细胞、单核细胞和NK细胞上有表达，在Th1细胞上不表达。 此外，CCR8在Treg细胞中也有表达，在肿瘤浸润的Treg细胞中高表达，在胸腺、脾脏和外周血的Treg细胞中表达量较低。 CCR8通过与其配体的相互作用参与了多种肿瘤的发展进程以及介导了肿瘤的免疫。 肿瘤部位的Treg上的CCR8特异性高表达表明CCR8是肿瘤部位的Treg细胞的非常好的生物标志物，是极 …

2022年3月30日 · Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, we investigated the...

2025年2月1日 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

2024年7月30日 · Chemokine (C-C motif) receptor 8 (CCR8) is a chemokine receptor selectively expressed on tumor-infiltrating regulatory T cells (Tregs). Strong immunosuppression mediated by CCR8 + Tregs observed in breast and lung malignancies suggest for their functional significance in cancer therapy.

High levels of expression of chemokine (C-C motif) receptor 8 (CCR8) discriminate Treg cells within tumours from those found in systemic lymphoid tissues. It has recently been proposed that disruption of CCR8 function using blocking anti-CCR8 antibodies results in reduced accumulation of Treg cells within tumours and disruption of their ...

2024年4月28日 · CC族趋化因子受体8（CC chemokine receptor 8，CCR8）属于CC族趋化因子受体家族，其主要在肿瘤微环境中的Treg细胞上特异性高表达，而在周围正常组织和外周血中低表达，因此CCR8可以作为Treg细胞的一种特异性标志物，是一种有潜力的治疗靶点和生物标志物。 本文对近年来CCR8在不同瘤种中的研究进展进行了归纳和总结，以期为后续研究提供参考。 [关键词] 肿瘤；CC族趋化因子受体8；免疫治疗；靶向治疗.

2023年9月1日 · Tumor-targeting drug conjugates are efficient drugs in which a cytotoxic payload is assembled into a carrier that binds Tregs via a linker. By allowing the drug to act...