Establishment of a murine model of acute-on-chronic liver failure …
The CCL4/APAP/LPS (CALPS) model of ACLF mimics the clinical, biochemical, and histological features of ACLF with demonstrable progressive hepatocellular necrosis, liver failure, impaired …
肝病研究常用的动物模型 - 知乎 - 知乎专栏
肝损伤造模一般通过腹腔注射或小鼠尾静脉注射特定化合物（如：CCl4、APAP、ConA、LPS&D-GalN等）即可，造模周期短。 通常肝损伤模型构建数小时后，小鼠即出现急剧的肝细胞死亡 …
BSA+CCL4+LPS-induced IgA Nephropathy Model - Cyagen
The IgAN model was constructed in BALB/c mice using the BSA+CCL4+LPS method. By the 8th week of modeling, spleen enlargement, glomerular mesangial proliferation, and glomerular IgA …
Establishment of a murine model of acute-on-chronic liver
2021年8月25日 · The CCL4/APAP/LPS (CALPS) model of ACLF mimics the clinical, biochemical, and histological features of ACLF with demonstrable progressive hepatocellular necrosis, liver …
Integrated temporal transcriptional and epigenetic single-cell …
LPS, a classical endotoxin derived from the outer membrane of Gram-negative bacteria, serves as an indispensable virulence factor that triggers Toll-like receptor-4 (TLR-4) inflammatory …
Toll-Like Receptor 4–Independent Carbon Tetrachloride–Induced …
We investigated carbon tetrachloride (CCl 4)–induced fibrosis and LPS-induced acute liver injury in wild-type (WT) and B6.B10ScN-Tlr4 lps-del /JthJ [TLR4-knockout (KO)] mice. Effects of LPS …
诱发性IgA肾病动物模型【实验外包】 - 知乎专栏
诱发性IgA肾病动物模型【实验外包】 【造模机制】BSA、脂多糖(lipopolysaccharides, LPS)和CCl4联合应用能够造成胃肠道黏膜免疫功能紊乱，引起机体对血液和肾小球中的过量IgA清除 …
自身免疫性肾炎 - GemPharmatech
ccl4诱导iga肾炎模型. 造模方式：使用balb/cjgpt 6-7w雌鼠，造模方法为牛血清白蛋白（bsa）、四氯化碳（ccl4）以及lps联合诱导iga肾炎模型。 数据展示. 与g1对照组相比，g2造模组尿总蛋 …
CCl_4和脂多糖诱导的急性肝损伤中肝细胞凋亡病理特点比较-【维 …
The mice of CCl4 model group received intraperitoneal injection of 50% CCl4 （0.03 mL/kg）, while the mice of LPS group were intraperitoneally injected with LPS （10 μg/kg） and …
Resveratrol improves CCL4-induced liver fibrosis in mouse by ...
We observed that resveratrol improved CCL 4-induced liver fibrosis, upregulated Kupffer cells, increased the expression of IL-10 and M(IL-4) marks including Mrc1, Mrc2, CD163 and Arg1, …