CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling.

2021年7月21日 · CD22 presents an attractive target in lymphoid neoplasms given its unique presence in B-lymphocytes. Due to its role in regulating B-cell function, CD22 has also been targeted in autoimmune diseases such as systemic lupus erythematosus and Sjogren syndrome.

CD22 is a transmembrane molecule that acts as a molecular switch to inhibit signaling by the B-cell receptor, leading to apoptosis instead of proliferation in stimulated B cells. It is strongly expressed in hairy cell leukemia and its expression pattern is similar to CD19. You might find these chapters and articles relevant to this topic.

CD22是一种可高度特异性识别糖基化蛋白（如 CD45）的 跨膜蛋白，可通过 N端 的一个 免疫球蛋白（Ig）结构域 （英语：immunoglobulin domain） 與 唾液酸 結合。 因擁有Ig结构域，CD22也属于 免疫球蛋白超家族 （英语：immunoglobulin superfamily）。 人类体内，CD22主要功能为抑制 B細胞表面受體 的活化。 另外，小鼠實驗的結果發現B细胞運輸至 派亞氏淋巴叢 的過程亦有CD22的參與。 [6] CD22是 B细胞受体 的一個 輔助受體 （英语：co-receptor），其與連結在 …

CD22 (Siglec-2）属于唾液酸结合免疫球蛋白型凝集素家族（Siglecs）成员，是一种I型跨膜蛋白，可特异性结合含唾液酸（Sia）的聚糖，并通过其免疫受体酪氨酸抑制性基序（ITIM）抑制B细胞受体（BCR）信号传导，发挥维持体液免疫稳态的作用。 （数据来源Lanza F, et al. Cancers. 2020） CD22在B细胞发育的早期主要在细胞内表达，包括pro-B和pre-B细胞，并且随着B细胞成熟度的提高，这种表达转移到跨膜。 CD22在成熟的B细胞中表达最高，并在大多数B细胞恶性肿 …

2024年12月24日 · CD22 (CD22 Molecule) is a Protein Coding gene. Diseases associated with CD22 include Hematologic Cancer and Trichomoniasis. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and Regulation of activated PAK-2p34 by proteasome mediated degradation.

CD22 is an inhibitory coreceptor of the B-cell receptor (BCR) and, like other coreceptors, is required to modulate the antigen receptor signal in response to cues from the local microenvironment. 1 This is essential to ensure that an appropriate humoral response is mounted against pathogens, but that reactivity to self antigens and autoimmunity ...

High and selective cytoplasmic expression in subsets of lymphocytes. Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas. All transcripts of all genes have been analyzed regarding the location (s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

2020年12月22日 · CD22限制性地表达于成熟B细胞和大多数恶性B淋巴瘤细胞表面，使其成为了自身免疫疾病和B细胞恶性肿瘤治疗的热门靶点之一，目前，以CD22为靶点的免疫治疗药物种类有单克隆抗体药物，抗体偶联物（ADC）以及CAR-T疗法。 B细胞受体CD22也称为唾液酸结合Ig样凝集素2（Siglec-2），B淋巴细胞细胞粘附分子（BL-CAM），T细胞表面抗原Leu-14，属于免疫球蛋白超家族和SIGLEC（唾液酸结合Ig样凝集素）家族。 CD22缺陷型小鼠的表型表明CD22主要 …

2018年9月27日 · CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized over 30 years ago and named “CD22” in 1984 at the 2nd International workshop in Boston (1). Several excellent reviews have detailed CD22 functions, CD22-regulated signaling pathways and B cell subsets regulated by CD22 or Siglec G (2 – 4).