CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.

CD8 deficiency is an extremely rare autosomal recessive disorder due to homozygous variants in the CD8A gene. CD8 is a T cell receptor (TCR) accessory molecule that interacts with the major histocompatibility complex (MHC). CD8 is found on cytotoxic T cells and NK cells.

Jan 15, 2025 · CD8 is a surface glycoprotein predominantly expressed on cytotoxic T-cells, a specialized subset of T-cells tasked with directly eliminating infected or malignant cells. Unlike CD4, CD8 binds to MHC class I molecules, which are present on nearly all nucleated cells.

Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...

Here we review recent advances in CD8 + T cell recognition of antigen in lymphoid as well as in nonlymphoid tissues in the periphery, and how CD8 + T cell expansion and differentiation are controlled in these contexts.

Sep 15, 2020 · Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies.

Cytotoxic CD8 + T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8 + T cell metabolism is coupled to transcriptional, translational and epigenetic changes that …