CD107a as a functional marker for the identification of ... - PubMed
Here we describe CD107a as a marker of NK cell functional activity using multi-parameter flow cytometry. CD107a is significantly upregulated on the surface of NK cells following stimulation …
Surface CD107a/LAMP-1 protects natural killer cells from degranulation ...
Aug 22, 2013 · In particular, CD107a/LAMP-1 has been widely used as a marker for degranulating cytotoxic lymphocytes, because surface expression is induced upon …
CD107a as a functional marker for the identification of natural killer ...
Nov 1, 2004 · Recently, lysosomal-associated membrane protein-1 (LAMP-1 or CD107a) has been described as a marker of CD8 + T-cell degranulation following stimulation. Here we …
Cytotoxic T Cell Overview | Thermo Fisher Scientific - US
CD107a glycoproteins line the luminal surface of resting T cells. Upon activation, lytic granules get localized to the site of interaction with the target cell and merge with the plasma membrane. …
CD107a：免疫细胞活性评价的又一利器——CD107a 流式检测方 …
Apr 18, 2023 · 在NK细胞和细胞毒性T细胞（CTL）中，CD107a是溶细胞颗粒中最丰富的蛋白质之一，它位于囊泡膜的内侧，其高度糖基化的部分隐藏在腔侧，短尾则暴露于细胞质中，与反式 …
A Modified NK Cell Degranulation Assay Applicable for Routine ...
Studies show that lysosome-associated membrane protein-1 (LAMP-1, CD107a) is a marker for degranulation of NK and cytotoxic T cells and its expression is a sensitive marker for the …
CD107a Degranulation Assay to Evaluate Immune Cell …
In this chapter, we detail the steps required to isolate peripheral blood mononuclear cells (PBMCs), coculture them with target tumor cell lines, and evaluate the cytotoxic immune …
LAMP1/CD107a is required for efficient perforin delivery to lytic ...
Jun 6, 2013 · Lysosome-associated membrane protein (LAMP) 1/CD107a is used as a marker for NK-cell degranulation, but its role in NK-cell biology is unknown. We show that LAMP1 …
Detection of T-Cell Degranulation: CD107a and b - ScienceDirect
Jan 1, 2004 · High-level expression of CD107a and b on the cell surface of activated T cells requires degranulation, because degranulation inhibitors, such as colchicine, dramatically …
Relationship between CD107a expression and cytotoxic activity
Studies show that CD107a (LAMP-1) may be a marker for degranulation of NK and activated CD8+ T cells. In our study, the relationship between the expression of CD107a, cytokine …
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