CD11b plays a protective role during SLE and lupus nephritis owing to its anti-inflammatory properties. Lupus nephritis is characterised by the accumulation of immune complexes in kidneys and overall immune infiltration into kidneys, which results in renal damage.

CD11抗原样家族成员B（CD11B）也被称作整合素alpha M（ITGAM），参与单核细胞、巨噬细胞和粒细胞的各种黏附相互作用。 调节中性粒细胞迁移、激活与凋亡。

CD11有4种亚家族成员（CD11a、CD11b、CD11c 和 CD11d）：CD11a是一种泛白细胞标志物，由B和T淋巴细胞、单核细胞、巨噬细胞、中性粒细胞、嗜碱性粒细胞和嗜酸性粒细胞表达；CD11b由大多数粒细胞、单核细胞/巨噬细胞、 NK 细胞 以及B细胞和T细胞亚群表达；CD11c在 …

常用的巨噬细胞标记物包括cd11b、cd14、cd16、 cd68 、 f4/80 （小鼠），cd80和cd86为常用的m1型巨噬细胞标记物，cd163和cd206为常用的m2型巨噬细胞标记物。

2025年2月11日 · CD11b is a critical marker in immunology, primarily associated with myeloid cells. Its significance extends beyond basic research, influencing our understanding of immune responses and disease processes. By examining CD11b’s roles, we gain insight into its importance in both normal physiological functions and pathological conditions.

Integrin αM (CD11b) is expressed in myeloid-lineage cells such as monocytes/macrophages, neutrophils, eosinophils, and basophils, and in lymphoid cells such as NK cells and peritoneal B-1 cells (Springer, 1994). Mac-1 binds multiple ligands, including ICAM-1 (CD54), ICAM-2 …

2023年7月7日 · cd11b是整合素cr3（也叫补体受体3）的α链，主要表达在巨噬细胞、单核细胞、中性粒细胞、nk细胞上，通过主要配体粘附分子（icam）介导细胞内外蛋白互作与信息交流。cd11b也常用作为上述几类细胞标志物。 表达cd11b的免疫细胞nk细胞cd11b与nk细胞成熟有关。

2015年4月22日 · Learn about CD11 and its role in adhesion-related association between cell and as a marker for macrophages and microglia, plus functional studies using CD11b antibodies.

CD11b is a protein on immune cells like macrophages and microglia, aiding in cell adhesion, migration, and immune response. It’s used in immune and neuro research.

cd11b是常见流式细胞技术，对于标记的细胞dna含量、细胞体积、蛋白质含量、酶活性有多种重要参数。 医生会根据此项的检查结果，判断患者的病情，进行针对性的药物治疗。