CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic ...

CD11c 是一种广泛应用树突状细胞的标志物(参考CD11c 蛋白和功能)。 它可被用来区分免疫系统中树突状细胞的亚型(参考CD11c在人类和鼠类免疫系统中的表达)，但是CD11c 对树突状细胞可能不仅仅是一个标志物(参考 CD11c和炎症)。

CD11c is a widely established marker for dendritic cells (see CD11c protein and function). It can be employed to determine the subsets of dendritic cells (DC) in the immune system (see CD11c expression in human and murine immune system), but CD11c may be more than a marker for DC cells (see CD11c and inflammation).

CD11有4种亚家族成员（CD11a、CD11b、CD11c 和 CD11d）：CD11a是一种泛白细胞标志物，由B和T淋巴细胞、单核细胞、巨噬细胞、中性粒细胞、嗜碱性粒细胞和嗜酸性粒细胞表达；CD11b由大多数粒细胞、单核细胞/巨噬细胞、 NK 细胞 以及B细胞和T细胞亚群表达；CD11c在 …

The leukocyte integrin CD11c is a myeloid marker expressed on most DCs (Table 1). CD11c + DCs can be further subdivided by their expression of CD8α, the alpha chain of the T-cell co-receptor CD8 (see [2] for a recent review of DCs).

2022年1月18日 · CD11c+ and CD11c− macrophages strongly expressed colony-stimulating factor (CSF)-1 receptor, the injection of an anti-CSF-1 receptor blocking antibody markedly reduced both subsets, and SGs ...

DC 大致分为浆细胞样和常规亚类。浆细胞样 DC 可通过 Siglec-H 和 CD317 的共同表达来检测，专门产生大量 I 型 IFNγ，而常规 DC 则通过 CD11c 和 HLA-DR 的共同表达来进行表征鉴定，它专门负责将抗原呈递给 T 细胞。

2021年3月12日 · Circulating CD11c + B cells are a key phenomenon in certain types of autoimmunity but have also been described in the context of regular immune responses (i.e., infections, vaccination). Using mass cytometry to profile 46 different markers on individual immune cells, we systematically init …

2018年6月26日 · CD11c, also known as integrin alpha X, is the most widely used defining marker for dendritic cells (DCs). CD11c can bind complement iC3b and mediate phagocytosis in vitro, for which it is also referred to as complement receptor 4.

2025年1月9日 · CD11c dendritic cells encompass a variety of subtypes, each with distinct origins, phenotypes, and roles in the immune system. These subtypes contribute to a nuanced orchestration of immune responses, ensuring both effective pathogen defense and maintenance of immune homeostasis.