CD133 antigen, also known as prominin-1, is a glycoprotein that in humans is encoded by the PROM1 gene. [5] [6] It is a member of pentaspan transmembrane glycoproteins, which specifically localize to cellular protrusions.When embedded in the cell membrane, the membrane topology of prominin-1 is such that the N-terminus extends into the extracellular space and the C-terminus resides in the ...

该研究团队开发了靶向 cd133-gsc的嵌合抗原受体巨噬细胞（car-mΦ）免疫疗法，用于清除肿瘤切除后残留的cd133-gscs。本项研究证实，在 神经胶质瘤 gbm小鼠模型中，靶向cd133-gscs，可发挥抗肿瘤免疫作用，抑制gbm术后的复发率，并减少抗肿瘤药物的毒副作用。

CD133 is expressed on both CSC and differentiated tumor cells. CD133 is possibly folded as a result of differential glycosylation to mask specific epitopes . Although both CD133 + and CD133-cells derived from primary glioblastomas show similar tumorigenicity in nude mice, there are 117 genes differentially expressing in these two subtypes .

目前CD133药物在临床前阶段， OXS-1650 是由University Of Minnesota研发针对CD133一款ADC药物，用来治疗卵巢上皮癌。CD133作为一种公认的CSC标志物，用于特异性鉴别不同种属CSC的来源及疾病诊断，广泛应用于神经系统肿瘤、前列腺癌、结直肠癌等的干性特征筛选。

CD133(Prominin-1)是五次跨膜糖蛋白Prominin家族的成员之一,最初作为特异性标志物用于筛选人造血干细胞和祖细胞,随后用于分离鉴定各种肿瘤干细胞的特定细胞亚群。研究表明,CD133是肿瘤治疗预后的标志物,能与血管内皮生长因子等物质相互作用,参与细胞通路的信号转导,在维持视网膜形态和功能中发挥着 ...

CD133 (also known as AC133 and prominin-1) is the most frequently used cell surface antigen to detect and isolate CSCs from various solid tumors , including brain, colon, pancreas, prostate, lung, and liver. There has recently been, however, some contrasting evidence of the accuracy associated with using CD133 as a marker for CSC detection and ...

2025年1月21日 · The CD133+PD-L1+ cancer cells exhibit tumorigenic potential. The CD133+PD-L1+ cells are further identified in the clinically metastatic melanoma. Hyperthermia reverses the resistance of CD133+PD ...

2013年7月1日 · Since CD133 was identified as a pentaspan transmembrane protein for human hematopoietic stem cells and mouse neuroepithelial cells [1–3], many studies have subsequently revealed that CD133 expression is associated with progenitor/stem cells, tumor, regeneration, differentiation, and metabolism.CD133 is one of key biomarkers for isolation and characterization of …

CD133 is a pentaspan transmembrane protein that plays a key role in tumorigenesis, metastasis, chemotherapy and radiotherapy resistance, and anti-apoptosis. It is expressed by stem cells in various cancers, including glioblastoma, colon, liver, and prostate cancers. AI generated definition based on: Journal of Clinical Neuroscience, 2018

CD133 participates in several cellular processes, in part orchestrating signal transduction of essential pathways that frequently are dysregulated in cancer, such as PI3K/Akt signaling and the Wnt/β-catenin pathway. CD133 expression correlates with enhanced cell self-renewal, migration, invasion, and survival under stress conditions in cancer.