CD137 is a costimulatory molecule functioning to stimulate T cell proliferation, dendritic cell maturation, and promotion of B cell antibody secretion. [7] As a T cell co-stimulator, T cell receptor (TCR) and CD28 signaling causes expression of CD137 on T cell membranes. When CD137 then reacts with the CD137 ligand, it leads to CD137 ...

2019年11月8日 · The expression of CD137 in immune cells and its role in promoting immune function against cancer have been well-characterized. In fact, CD137 agonists have been tested as anticancer agents with some success . However, the biological significance of CD137 expression in cancer still remains unclear.

2019年10月31日 · It functions as an immune suppressor, enhancing Treg expansion and ameliorating T H 17 autoimmune effects. 17 Conversely, CD137 is a potent immune stimulator that has been found to modulate the tumor microenvironment, enhancing T- and NK-cell cytotoxicity and their infiltration into tumors. 18,19 CD137 agonistic monoclonal antibodies are ...

2010年4月15日 · CD137, also known as 4-1BB, is a member of the TNFR super family. CD137 is closely related to CD27, OX40, and CD30. It is up-regulated on mouse and human T cells upon activation. 2 It has long been recognized as a costimulatory molecule for T cells.

2014年1月5日 · CD137 signaling regulates T-cell proliferation and survival, particularly within the T-cell memory pool , can upregulate Bcl-X L antiapoptotic protein expression and supports CD8 + T-cell expansion .

2024年11月5日 · Here, we report updates for CD137+ VETc in murine models, findings for CD137+ VETc in primary human AML cells, and validation of TGF-β signaling inhibition in VETc via SMAD2 knockout to counter immunosuppression.

2021年1月26日 · The CD137 receptor (4-1BB, TNF RSF9) is an activation induced molecule expressed by antigen-specific T-cells. The engagement with its ligand, CD137L, is capable of increasing T-cell survival, proliferation, and cytokine production. This allowed to identify the CD137+ T-cells as the real tumor-specific activated T-cell population.

2014年1月5日 · CD137 + TILs produced significantly more IFN-γ than PD-1 + cells upon tumor stimulation. As CD137 expression on T cells is transient in response to stimulus, CD137 + TILs represent a group of newly recruited T cells.

2013年5月16日 · CD137 is a co-stimulator that belongs to the tumor necrosis factor receptor superfamily. CD137 is induced on activated T cells by the TCR signal, and this augments the proliferation and differentiation of these T cells.

Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials.