CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal compartment. CD14 can be expressed by cells of both hematopoietic and non-hematopoietic origin as a cell membrane or secreted protein. Although CD14 was discovered ...

2019年8月1日 · Therefore, membrane-bound forms of CD14 (mCD14) is anchored on the surface of cell membrane by GPI tail. Soluble forms of CD14 (sCD14) could be secreted by activated cells which release CD14 by proteinase dependent (48 kDa) or independent shedding (55 kDa) [1]. mCD14 is highly expressed on myeloid lineage cells, such as monocytes, macrophages ...

CD14 is biologically active as either a monomeric protein attached to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor (mCD14) or as a secreted soluble protein (sCD14) that enables epithelial and endothelial cells to respond to LPS . Known CD14 ligands, including PAMPs and DAMPs are listed in Table 1.

1999年5月1日 · The GPI-anchored 55 kDa glycoprotein CD14 is expressed on monocytes/macrophages and to a lesser extent on granulocytes. Engagement of CD14 by ligands like lipopolysaccharide, intact bacteria or apoptotic cells can result in either pro- or anti-inflammatory responses. Since the CD14 molecule does not have a membrane spanning domain it …

CD14. CD14 is a lipopolysaccharide-binding protein, which functions as an endotoxin receptor. It is anchored to the cell surface by linkage to GPI. CD14 is strongly positive in monocytes and most tissue macrophages, but is weakly expressed or negative in monoblasts and promonocytes.

In contrast, increased intracellular Ca 2+ induced by antibody cross-linking of CD14 is favored in cells bearing GPI-anchored CD14. The present results distinguish functions of CD14 that require the presence of its GPI anchor from those that can be carried out equally well with GPI-anchored or transmembrane forms of the protein.

2025年3月18日 · CD14 plays a pivotal role in the LPS-TLR4 signaling pathway by recognizing LBP-delivered LPS and presenting it to TLR4, making LPS the first and most extensively studied CD14 ligand. CD14 exists in two forms: a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein and a soluble serum protein lacking the GPI tail, both capable of ...

CD14也是革兰氏阳性菌细胞壁成分肽聚糖(peptidoglycan， PGN)、分枝杆菌上的脂阿拉伯甘露糖(lipoarabinomannan)及多种病原体的受体[8]。 6. CD14的功能 CD14是一种锚定蛋白，是一种普遍存在的模式识别受体。CD14作为细菌脂多糖LPS的细胞膜受体，它与其他蛋白质协同作用 ...

The GPI-anchored 55 kDa glycoprotein CD14 is expressed on monocytes/macrophages and to a lesser extent on granulocytes. Engagement of CD14 by ligands like lipopolysaccharide, intact bacteria or apoptotic cells can result in either pro- or anti-inflammatory responses. Since the CD14 molecule does not have a membrane spanning domain it cannot ...

2020年11月9日 · CD14 is a GPI-linked receptor (i.e., lacks a cytoplasmic domain), which likely enables faster lateral mobility than the transmembrane TLR2. Whether this contributes to its ability to rapidly bind ...