Role of CD14 in human disease - PMC - PubMed Central (PMC)
The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages …
Exogenous heat shock proteins HSPA1A and HSPB1 regulate TNF …
We also observed that CD14 affects the secretion levels of IL-1β, TNF-α and IL-10 from cells in response to exogenous HSP treatment. In addition, HSPA1A and HSPB1 were shown to …
HSP70 stimulates cytokine production through a CD14 …
These findings indicate that CD14 is a co-receptor for HSP70-mediated signaling in human monocytes and are indicative of an previously unrecognized function for HSP70 as an …
Cutting edge: heat shock protein (HSP) 60 activates the innate ... - PubMed
2001年1月1日 · CD14, the monocyte receptor for LPS, binds numerous microbial products and can mediate activation of monocytes/macrophages and endothelial cells, thus promoting the …
Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate …
2000年1月1日 · We show here that human HSP60 activates human PBMC and monocyte-derived macrophages through CD14 signaling and p38 mitogen-activated protein kinase, sharing this …
Soluble CD14 is a nonspecific marker of monocyte activation
Soluble CD14 is associated with morbidity and mortality in HIV disease. It is a co-receptor for lipopolysaccharide (LPS) that is released from monocytes upon activation. We demonstrate …
Heat shock protein 70 is a potent activator of the human …
In a recent study, like Hsp60, the inducible form of Hsp70 stimulated cytokine (tumor necrosis factor-α, interleukin (Il)-1β, and Il-6) production through a CD14-dependent pathway in human …
Exogenous heat shock proteins HSPA1A and HSPB1 regulate
2023年8月15日 · HSP interaction with CD14, CD36 and CD11b was further investigated using blocking peptides. The results showed that both HSPA1A and HSPB1 were able to interact …
外源热休克蛋白 HSPA1A 和 HSPB1 调节单核细胞的 TNF-α、IL-1β
我们还观察到 cd14 影响细胞响应外源 hsp 治疗的 il-1β、tnf-α 和 il-10 的分泌水平。 此外，HSPA1A 和 HSPB1 与 CD14、CD36 和 CD11b 细胞外受体蛋白相互作用。 本研究中使用的 …
CD14: Biology and role in the pathogenesis of disease
2019年8月1日 · CD14 works as a multi-talented receptor to relay context dependent signals that regulate the inflammation outcome. To define CDs activities in different context, in this review, …