Human Dermal CD14 + Cells Are a Transient Population of …
2014年9月18日 · In this study, we investigated the relationships between circulating blood CD14 + monocytes and tissue macrophages with tissue MHC classII + CD14 + cells, currently defined as “DCs.” We defined the transcriptomic profile of the human monocyte-macrophage lineage distinct from the DC lineage and demonstrated the conserved gene transcripts ...
CD14的介绍：白细胞分化抗原与LPS受体的双重身份解析
2024年4月2日 · 根据CD14在体内的存在形式，分为存在于细胞表面的膜结合型CD14（membranebound CD14，mCD14）和血浆内的sCD14。 mCD14是一种分子量为5.3万～5.5万的糖蛋白，主要通过糖基磷脂酰肌醇（glycosylphosphatidylinositol，GPI）锚着在细胞膜上，少数mCD14也可通过跨膜肽与细胞膜结合 ...
Multifaceted role of CD14 in innate immunity and tissue …
2023年12月1日 · CD14, a co-receptor for TLR4, recognizes LPS, PAMPs, and DAMPs in innate immunity. CD14 has a role in TLR4-dependent and TLR4-independent signaling pathways. CD14 helps clear apoptotic cells by recognizing phospholipids externalized on the cell surface. In barrier tissues, CD14 can mediate inflammatory and tolerogenic responses.
CD14, CD16 and HLA‐DR reliably identifies human monocytes and …
2012年7月26日 · CD14 hi /CD16 pos monocytes express the highest levels of MHC II and accessory molecules, exhibit high levels of phagocytosis and produce the highest amounts of both pro and anti-inflammatory cytokines in response to TLR4 agonist stimulation (8, 11).
Monocyte differentiation and antigen-presenting functions
2017年4月24日 · Monocytes are antigen-presenting cells that load antigen on MHC class I and II molecules and prime CD8 + and CD4 + T cells. Monocytes have both pro-inflammatory and anti-inflammatory properties....
CD14: Cell surface receptor and differentiation marker
1993年1月1日 · In the past, CD14 has been viewed simply as a useful marker molecule for monocytes and macrophages. Now, new findings on its role in binding of LPS-LBP complexes and in signal transduction have engendered renewed interest in the properties of CD14.
Single-cell profiling reveals distinct subsets of CD14+ monocytes …
To elucidate whether the upregulation of inflammatory and MHC-II genes in intermediate CD14 + CD16 + monocytes in ATB patients at diagnosis were associated with functional changes, we investigated the ability of this monocyte subset to activate T …
Changes in Expression of the Membrane Receptors CD14, MHC-II …
IL-10 increased the expression of the defensive receptor SR-A and decreased the expression of CD14, TLR4, and the antigen-presenting molecule MHC-II in all types of macrophages examined, regardless of hyperlipidemic state. These data are consistent with …
Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and
2023年1月25日 · CD14 + CD8 + T cells exhibit increased turnover, activation and constitutive immunomodulatory features with high homeostatic IL-10 and IL-2 production ex vivo, and enhanced antiviral/anti-tumour...
内毒素相关受体：sCD14与mCD14结构与功能的异同解析
2024年4月2日 · CD14弱阳性细胞可表达CD16、 CD11b、CD33和MHC ClassⅡ抗原，提示这两群单核细胞亚群间可能存在着一定的功能差异。 同单核细胞相似，组织巨噬细胞表面mCD14的表达强度也存在一定差异，如腹腔、胸腔巨噬细胞、脾巨噬细胞、kupffer细胞、脑血管周围巨噬细胞以及肉芽肿内的上皮样细胞、多核巨细胞均可表达较高水平mCD14，而肺泡巨噬细胞、小神经胶质细胞却仅显CD14弱阳性。 体外研究显示，单核细胞衍生的巨噬细胞表面mCD14的表达，因培 …