Cell Reports丨CD14在细胞内LPS传感中的独立于TLR4的关键作用
By generating Cd14−/− and Casp11−/− mice strains on a Tlr4−/− background, we dissociate CD14's known role in TLR4 signaling from its role in caspase -11 activation and show a TLR4 …
TLR4 and CD14 trafficking and its influence on LPS-induced pro ...
In this review, we focus on the mechanisms of the internalization and intracellular trafficking of TLR4 and CD14, and also of LPS, in immune cells and discuss how dysregulation of the endo …
CD14 controls the LPS-induced endocytosis of Toll-like Receptor 4
We hypothesized that CD14 expression would naturally endow TLR4-bearing cells with the ability to promote TLR4 endocytosis, thus providing a mechanism of cell type-specific control over …
Multifaceted role of CD14 in innate immunity and tissue …
2023年12月1日 · CD14 is a co-receptor of Toll-like receptor (TLR)− 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage …
Role of CD14 in human disease - PMC
The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages …
A TLR4-independent critical role for CD14 in intracellular LPS …
2022年5月3日 · By generating Cd14−/− mice on a Tlr4 -deficient background, we reveal that CD14 plays an essential TLR4-independent role in caspase-11 activation in vivo by delivering …
Targeting the TLR co-receptor CD14 with TLR2-derived peptides ... - PubMed
2013年5月15日 · We assessed the potential of the TLR co-receptor CD14 as a target for therapeutics by investigating the magnitude of its influence on TLR responses. We studied the …
An examination of the LPS-TLR4 immune response through the …
2025年3月18日 · The LPS-TLR4 immune response is a critical mechanism in the body's defense against Gram-negative bacterial infections, yet its dysregulation can lead to severe …
CD14 is critical for TLR2-mediated M1 macrophage activation
2017年8月1日 · Because co-receptors influence agonist binding to TLRs, we investigated whether CD14 is required for macrophage activation induced by ArtinM.
Pattern recognition receptors TLR4 and CD14 mediate …
Our studies reveal that RSV F protein induced interleukin 6 (IL-6) production by monocytic cells expressing CD14 and TLR4. RSV G and N proteins induced weaker cytokine responses than …