Thrombomodulin (TM), CD 141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. [5] .

2016年12月2日 · The first functional analyses point to a high pro-inflammatory state of CD141+ compared to CD141- monocytes. Therefore we hypothesize that these monocytes may contribute to an immune stimulatory environment in low risk MDS patients with potentially a favourable prognostic value.

2016年8月8日 · Intratumoral dendritic cells (DC) bearing CD103 in mice or CD141 in humans drive intratumoral CD8 + T cell activation. Using multiple strategies, we identified a critical role for these DC in trafficking tumor antigen to lymph nodes (LN), resulting in both direct CD8 + T cell stimulation and antigen hand-off to resident myeloid cells.

2019年3月6日 · By in vitro gene expression profiling of differentiated human DCs, we identified CD141 and CD163 as surface markers for DC-10. The coexpression of CD141 and CD163 in combination with CD14 and...

Human CD141 + dendritic cells (DCs), specialized for cross-presentation, have been extensively studied in the development of DC-based therapy against cancer. A series of attempts was made to generate CD141 + DCs from cord blood CD34 + hematopoietic progenitors to overco …

2017年10月29日 · Here, we exploit the fact that human CD141 + DC and CD1c + DC develop in humanized mice, to further explore their equivalency in vivo. Global transcriptome analysis of CD141 + DC and CD1c + DC isolated from humanized mice demonstrated that they closely resemble those in human blood.

Here, we identified a CD141 hi DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c + and CD14 + tissue DCs and superior at cross-presenting soluble antigens. Cutaneous CD141 hi DCs were closely related to blood CD141 + DCs, and migratory counterparts were found among skin-draining lymph node DCs.

Results: Almost one third of liver CD11c (+) myeloid DCs (mDCs) expressed CD141 compared to <5% of circulating mDCs. Hepatic CD141 (+) DCs demonstrated pro-inflammatory function in allogeneic MLRs, inducing T cell production of interferon gamma (IFN-γ) and interleukin (IL)-17.

2025年2月27日 · Chu et al. 11 identified a unique population of immunoregulatory tissue-resident DCs known as CD141 + dermal dendritic cells (CD141 + DDCs), in human skin. These cells expressed CD141 and CD14 and constantly secreted IL-10, showing characteristics associated with immune tolerance.

2010年6月7日 · We report the first detailed functional analysis of the human CD141+ DC subset. CD141+ DCs are found in human lymph nodes, bone marrow, tonsil, and blood, and the latter proved to be the best source of highly purified cells for functional analysis.