2020年6月30日 · In our pervious study, CD147 expression was documented to increase in intestinal tissue of inflammatory bowel disease (IBD). Objective: The aim of this study was to determine the function of serum CD147 in pyroptosis. Methods: The study group consisted of 96 cases. The centration of CD147, IL-1 β, and IL-18 levels in serum was assessed by ELISA.

In this study, to our knowledge, we are the first to investigate the expression and clinical prognostic significance of CD147 in IBD. The expression of CD147 is increased in the intestinal mucosa of patients with IBD, and serum CD147, associated with DAI, is higher in inflamed patients than in noninflamed patients, which suggested that CD147 ...

In our pervious study, CD147 expression was documented to increase in intestinal tissue of inflammatory bowel disease (IBD). The aim of this study was to determine the function of serum CD147 in pyroptosis. The study group consisted of 96 cases. The centration of CD147, IL-1 β, and IL-18 levels in serum was assessed by ELISA.

2020年9月15日 · Objective: The aim of this study is to explore the clinical significance of CD147 in the pathogenesis of inflammatory bowel disease (IBD). Results: In addition to monocytes, the clinical analysis showed that there is no significance obtained in leucocyte, neutrophil, eosinophil, basophil, and erythrocyte between IBD and controls.

2020年7月2日 · 在本研究中，我们的结果表明，CD147 通过增强 IEC 中 IL-1 β和 IL-18 的表达和分泌来诱导肠上皮细胞 (IEC) 细胞焦亡，这归因于炎症小体的激活，包括 caspase-1 和 GSDMD以及 GSDME，导致聚集炎症反应。

In our pervious study, CD147 expression was documented to increase in intestinal tissue of in ammatory bowel disease fl (IBD). Objective. The aim of this study was to determine the function of serum CD147 in pyroptosis. Methods. The study group consisted of 96 cases. The centration of CD147, IL-1β, and IL-18 levels in serum was assessed by ELISA.

AC-73 inhibited CD147/ERK1/2 and STAT3 signalling pathway activation and induced autophagy. Conclusions. CD147 is a potential new target for controlling intestinal fibrosis and its inhibitor, AC-73, might represent a potential new anti-fibrotic therapeutic option in IBD. Keywords: Intestinal fibrosis, CD147, autophagy. 1. Introduction

2022年11月23日 · CD147 inhibition by AC-73 treatment reduced intestinal fibrosis, collagen and cytokine mRNA tissue content, without significant modulation of activated TGF-β1 protein tissue content. AC-73 inhibited CD147/ERK1/2 and STAT3 …

2023年1月1日 · Also, another study reported that the increased level of CD147 in the intestinal mucosa could be a helpful biomarker for the diagnosis of inflammatory bowel disease (IBD) in children, and this is possible because of the high expression of MCT4, a regulator of like CD147, MMP-2 and MMP-9 [117].

2020年9月16日 · In this study, to our knowledge, we are the first to investigate the expression and clinical prognostic significance of CD147 in IBD. The expression of CD147 is increased in the intestinal mucosa of patients with IBD, and serum CD147, associated with DAI, is higher in inflamed patients than in noninflamed patients, which suggested that CD147 ...