2023年9月25日 · In this study we constructed a novel radiotracer by labeling the anti-CD147 mAb with radionuclide 124/125 I (124/125 I-anti-CD147) for noninvasive detection of CD147 expression in...

2020年11月11日 · Here, we show that deletion of CD147, a type I transmembrane molecule, in T cells, strongly limits in vivo tumor growth of mouse melanoma and lung cancer in a CD8+ T-cell-dependent manner.

2023年1月1日 · CD147 contains an extracellular domain with immunoglobulin loops joined to oligosaccharides that are asparagine (Asn)-linked. In addition, CD147 contains a cytoplasmic and a short single transmembrane domain (Fig. 1A). The expression of CD147 has been identified in both physiologic and pathologic situations.

CD147 is a glycoprotein involved in the regulation of the tumor microenvironment and cancer progression by several mechanisms—in particular, by the control of glycolysis and also by its well-known ability to induce proteinases leading to matrix degradation, tumor cell invasion, metastasis and angiogenesis.

2020年3月30日 · 最新研究表明，氧化型低密度脂蛋白能够促进血小板中CD147表达，而CD147能够通过MMPs降解细胞外基质，进而导致动脉粥样硬化斑块破裂或不稳定。

2024年2月27日 · CD147, also known as EMMPRIN, is a trans-membrane glycoprotein that regulates T cell maturation, adhesion, and activation [9,10]. CD147 also binds to plasma membrane calcium ATPase isoform 4 (PMCA4) to reduce IL-2 cytokine production and bypass TCR proximal signaling in Jurkat T cells and primary CD4+ T cells [11].

CD147，也称为 basigin， Emmprin，是一种跨膜糖蛋白，Ig超家族的成员之一，被认为是细胞外基质金属蛋白酶（MMP）的有效诱导剂，能够诱导各种MMP的合成。 CD147分子及其与单抗E11F4之间的作用. （引自Nabeshima et al. 1999） 上图展示的是CD147分子示意图，CD147定位于质膜上，由两个胞外免疫球结构域（ECI和ECII）、一个跨膜结构域和一个胞内结构域组成。 该单克隆阻断抗体EIIF4与ECI发生反应，激活ECI区域的免疫活性。 胞外结构域中的180位脯氨 …

Negative regulation of antitumor T-cell-immune responses facilitates tumor-immune escape. Here, we show that deletion of CD147, a type I transmembrane molecule, in T cells, strongly limits in vivo tumor growth of mouse melanoma and lung cancer in a CD8 + T-cell-dependent manner.

CD147 或 EMMPRIN 是人类免疫球蛋白超家族的成员。 它在人类肿瘤中广泛表达，并通过刺激基质金属蛋白酶 (MMP) 和细胞因子的分泌在许多癌症的进展中发挥核心作用。

2021年1月5日， 空军军医大学 国家分子医学转化中心 陈志南 院士团队在 Cell Metabolism 上发表题为 “Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export” 的研究成果， 该研究阐述了CD147-K234二 甲基化 修饰 （CD147-K234me2） 增强CD147和MCT4的相互作用 ...