2021年2月19日 · 这项研究发现了 恶性脑肿瘤免疫治疗的一个潜在新靶点——cd161。目前的研究显示，cd161作为一种抑制免疫t细胞抗癌活动的分子，一直在抵抗基于人体免疫系统的突破性癌症治疗方法，即免疫疗法的应用。

Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene. [5] Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation.

对克隆扩增肿瘤浸润T细胞的分析进一步确定NK基因KLRB1 (编码CD161)为候选抑制受体。 因此，KLRB1基因失活或抗体介导的CD161阻断剂增强了T细胞介导的胶质瘤细胞体外杀伤和体内抗肿瘤功能。 在其他人类癌症中，大量T细胞群体也表达KLRB1及其相关转录程序。 本研究提供了神经胶质瘤中的T细胞图谱，并突出了CD161和其他NK细胞受体作为免疫治疗靶点。 实验设计. 31例成年胶质瘤患者的新鲜肿瘤样本中分离出的浸润T细胞进行全长或者5’端单细胞RNA测序，并对 …

2015年7月29日 · The C-type lectin-like receptor CD161 is expressed by lymphocytes found in human gut and liver, as well as blood, especially natural killer (NK) cells, T helper 17 (Th17) cells, and a...

CD161，别名NKRP1A（NK受体P1A）、KLRB1、CLEC5D，以下均称为CD161。其中，KLRB1（killer cell lectin-like receptor subfamily B1）是推荐的名称，中文翻译为“杀伤细胞的类凝集素受体亚家族B成员1号”。CD161目前只发现一种序列，没有其他变体。

High levels of CD4+CD161+ Tem are associated with improved survival and our data show that CD161 is dynamically regulated by cell intrinsic and extrinsic factors. CD161 expressing CD4+ T cells rapidly respond to suboptimal antigen stimulation suggesting that CD161, similar to SOX4, is involved in th …

2014年11月6日 · T lymphocytes are conventionally divided into subsets based on expression of coreceptors, cytokines, and surface molecules. Using CyTOF and mRNA microarray analysis, Fergusson et al. identify T lymphocytes that express the C-type lectin CD161 to share a transcriptional profile and innate function across these previously defined subsets.

2018年4月8日 · CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations.

Expression of killer cell lectin-like receptor B1 (KLRB1), the gene encoding the cell surface molecule CD161, is associated with favorable prognosis in many cancers. CD161 is expressed by several lymphocyte populations, but its role and regulation …

Human C-type lectin-like CD161 is a type-II transmembrane protein expressed on the surface of various lymphocytes across innate and adaptive immune systems. CD161+ T cells displayed enhanced ability to produce cytokines and were shown to be enriched in the gut.