Chemokine receptor CXCR3 is a Gα i protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. There are three isoforms of CXCR3 in humans: CXCR3-A, CXCR3-B and chemokine receptor 3-alternative (CXCR3-alt). [5] .

趋化因子受体CXCR3 是G蛋白偶连的七跨膜域受体，可选择性地与CXC 趋化因子 （CXCL9， CXCL10，和 CXCL11）结合 [1]。 CXCR3又称G蛋白偶联受体9 (GPR9)和CD183。 有两种变异的CXCR3受体。 CXCR3－A与CXCL9， CXCL10，CXCL11结合；而CXCR3-B除了与CXCL9， CXCL10，CXCL11结合外还可以与 CXCL4 结合 [2]。 CXCR3主要表达在 T细胞 、 自然杀伤细胞 活性上 [3]，有的 上皮细胞 和一些 内皮细胞 也表达CXCR3。 I型 辅助T细胞 （Th1）优先表 …

2024年12月24日 · CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

目前，人类 CD 抗原编号现已达到 CD363。 在该命名系统中，特定细胞群表面的特异性抗原存在与否分别用“+”（是）或“-"（否）标注，并用 hi（高）或 low（低）标记细胞表达水平。 例如，中央记忆型 T 细胞的编号为 CD62Lhi，而效应记忆型 T 细胞则为 CD62Llow。 监测不同 CD 抗原的表达谱使得基于细胞在不同免疫过程中的功能的细胞类型鉴定、分离和表型分型成为可能。 下面的表中汇总了目前命名的 CD 分子，用户可通过该表确定感兴趣的靶标。 单击各靶标即可获取更 …

趋化因子受体的CXC亚群 CXCR3 主要表达在活化的T细胞、B细胞和自然杀伤细胞的表面，并通过与靶细胞膜上的特定受体结合以诱导靶向迁移和免疫应答，在感染、自身免疫疾病和肿瘤免疫中发挥重要作用。 CXCR3及其配体 CXCL9 、 CXCL10 和 CXCL11 与许多肿瘤的发展和进展密切相关。 随着其作用机制的阐明，CXCR3有望成为评估肿瘤患者预后的新指标和临床肿瘤免疫治疗的新靶点。 趋化因子受体CXCR3由三种 IFN-γ 诱导配体CXCL9、CXCL10和CXCL11激活诱导。 …

The CXCR3-173 monoclonal antibody reacts with mouse CXCR3 also known as CD183, a 38 kDa chemokine receptor for CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (ITAC). CXCR3 is expressed primarily on activated T cells, NK cells, as well …

2011年3月10日 · CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4 (+) T cells and effector CD8 (+) T cells.

CD183, also called CXCR3, is a 41 kDa transmembrane G protein-coupled CXC receptor, belonging to the family of chemokine receptors. It has selectivity for IP10, Mig and I-TAC chemokines. Cellular production of CD183 ligands is induced by interferon, suggesting an important role of CD183 in Th1-type inflammatory processes.

It is a 38 kD seven-pass transmembrane receptor coupled to G-protein. CXCR3 is highly expressed by T cells (Th1), natural killer cells (NK cells), dendritic cells, mast cells, alveolar macrophages, eosinophils, and human airway epithelial cells.

CD183, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein.