A synthetic human 3D - ScienceDirect
2023年1月20日 · 3D cultures of CD19 + B-cells induce a significant increase in B-cells and antibody production
3D-organoid culture supports differentiation of human CAR - Cell …
2022年4月7日 · We report that iPSCs reprogramed from CD62L + naive and memory T cells followed by CD19-CAR engineering and 3D-organoid system differentiation confers products …
6AL5: COMPLEX BETWEEN CD19 (N138Q MUTANT) AND B43 FAB …
Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold. CD19 is a transmembrane protein expressed on malignant B cells, but not in other …
Frontiers | Getting CD19 Into Shape: Expression of Natively Folded ...
2020年2月6日 · Here, we successfully expressed a novel fusion construct consisting of the full-length extracellular domain of CD19 and domain 2 of human serum albumin (CD19-AD2), …
mRNA‐laden lipid nanoparticle‐enabled humanized CD19 …
Humanized CAR mRNA targeting CD19 was encapsulated into LNPs using microfluidic mixing, achieving efficient transfection and robust CAR expression. Engineered CAR‐T cells exhibited …
3D-organoid culture supports differentiation of human CAR
2022年4月7日 · We report that iPSCs reprogramed from CD62L + naive and memory T cells followed by CD19-CAR engineering and 3D-organoid system differentiation confers products …
Efficacy and safety of CD19 CAR T constructed with a new anti-CD19 ...
Recent evidence suggests that resistance to CD19 chimeric antigen receptor (CAR)-modified T cell therapy may be due to the presence of CD19 isoforms that lose binding to the single-chain …
CD19 CAR antigen engagement mechanisms and affinity tuning
CAR T cells targeting CD19 were the first to achieve dramatic clinical responses in patients with relapsed/refractory B cell malignancies and to be approved by the U.S. Food and Drug …
3D类器官培养支持人类CAR+iPSC分化为高功能CART细胞
2022年10月8日 · 我们报道了从CD62L+幼稚T细胞和记忆T细胞中重新编程的诱导多能干细胞，然后进行CD19-CAR工程和3D类器官系统分化，获得了具有传统CD8αβ阳性CAR-T细胞特征的 …
CD19 Gene - Somatic Mutations in Cancer - Wellcome Sanger …
CD19 - Explore an overview of CD19, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.
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