CD1a (C luster of D ifferentiation 1a) is a human protein encoded by the CD1A gene. [3] This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin.

cd1a蛋白是一种跨膜蛋白，属于cd1家族，它在免疫系统中发挥重要作用。cd1家族包括cd1a、cd1b、cd1c和cd1d，它们与抗原呈递和t细胞免疫反应密切相关：与经典的主要组织相容性复合物（mhc）相比，cd1蛋白在抗原呈递…

2024年12月24日 · CD1A (CD1a Molecule) is a Protein Coding gene. Diseases associated with CD1A include Histiocytosis and Langerhans Cell Histiocytosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

cd1（分化簇1）分为cd1a（r4），cd1b（r2），cd1c（r7），cd1d（r3）和cd1e（r2）五种。它们与mhcⅠ类分子的结构相似，可以提呈脂质或者糖脂质的抗原。另外，nkt细胞也只能接受由cd1d递呈的抗原。通常cd1分子在所有apc（抗原递呈细胞）和胸腺皮质细胞上都有表达。

CD1a（Cluster of Differentiation 1a）是身上的一種人類蛋白质，由基因「CD1A」轉譯而成 [3] 。 該蛋白屬於CD1蛋白家族，為一種穿膜醣蛋白。CD1a與β2-微球蛋白共同構成的異源二聚體（heterodimers）稱為「CD1a複合體」（CD1a complex），在結構上類似MHC I分子。

CD1a is distinguished by the small volume of its antigen-binding groove and its stunted A′ pocket, its high and exclusive expression on Langerhans cells, and its localization in the early endosomal and recycling intracellular trafficking compartments. Its ligands …

Alteration of CD1a-dependent T-cell responses has recently been discovered to contribute to the pathogenesis of several inflammatory skin diseases. We overview the structure and role of CD1a and outline the current evidence implicating CD1a in the development of psoriasis, atopic dermatitis and allergic contact dermatitis. Introduction

CD1 molecules present foreign and self lipids to diverse T cells and natural killer T (NKT) cells. Whereas the clonally restricted diverse T cells mediate adaptive immunity to microbial lipid...

cd1a 分子： 该基因编码跨膜糖蛋白 cd1 家族的成员，其在结构上与主要组织相容性复合体 (mhc) 蛋白相关，并与 β-2-微球蛋白形成异二聚体。 cd1 蛋白介导自身或微生物来源的主要脂质和糖脂抗原向 t 细胞的呈递。

2003年1月1日 · Four human CD1 proteins — CD1A, CD1B, CD1C and CD1D — present lipid antigens by insertion of lipids into a groove in the proteins to form CD1–lipid complexes. These complexes activate T cells...