2023年10月5日 · Here, we describe UCART2, a novel CD2-targeting allogeneic CAR-T therapy in which the biallelic deletion of CD2 and TRAC prevents fratricide and life-threatening GvHD …

T cells bearing chimeric antigen receptors (CARs) are broadly categorised into first- and second-generation receptors. Second-generation CARs contain a co-stimulatory signalling molecule …

2021年11月25日 · 在临床前模型中，CD58改变可降低CAR-T细胞活化和细胞毒性。 克服共刺激配体缺乏的策略 通过添加第二个CAR结构（CAR胞质尾部结合有CD2信号结构域），可以克 …

Co-stimulation of T cells with CD2 augments CD3-mediated signaling cascades, IL-2 production, and proliferation. The field dedicated to the development of novel second- and third-generation …

We found that incorporation of an engineered T cell receptor CD3ε motif, E B6I, into the conventional 28Z or BBZ CAR induced self-phase separation through cation-π interactions. E …

2024年11月5日 · Incorporation of CD2 binding into the TRIEC molecule increases cytotoxicity without eliciting nonspecific activation or unstimulated proliferation of CAR-T cells in the …

2022年2月16日 · We successfully built tricistronic constructs that expresses the CAR, a dnTGFBR2 module and a switch receptor for PD1 and CD28. We compared the 41BB …

To broaden the use of CAR-T cells in pan T-cell malignancies, we developed an allogeneic "universal" CD2-targeting CAR-T cell (UCART2), in which the CD2 antigen is deleted to …

2025年1月6日 · We find that different CAR/antigen sizes, which are generated by different CAR architectures and different target antigens, require a different CD2/CD58 size to optimise …

To broaden the use of CAR-T cells in pan T-cell malignancies, we developed an allogeneic “universal” CD2-targeting CAR-T cell (UCART2), in which the CD2 antigen is deleted to …