2021年9月20日 · CD20 is a common B cell marker also called L26, membrane spanning 4 domains (MS4A1).

Typical IHC results of DLBCL NOS are characterized by large, atypical CD3-negative and CD20-positive lymphocytes with a Ki-67 labeling index greater than 80%. Further, the cell of origin (COO) classification is performed by staining for CD10 (cut off: 30%), Bcl-6 (cut off: 30%), and MUM-1 (multiple myeloma 1) (cut off: 30%) through the Hans ...

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP,... Antibodies that detect CD20 can be used in several scientific applications, including Immunohistochemistry, Flow Cytometry, Western Blot, Immunocytochemistry and ELISA. These antibodies target CD20 in Human, Mouse, Canine, Rat and Rhesus Monkey samples.

2022年4月19日 · A special technique called immunohistochemistry (IHC) is used to identify CD20 and determine whether an abnormal cancerous white blood cell (lymphocyte in particular) is a B-cell or T-cell.

CD20 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Here we show both the molecular mechanisms and the clinical significance of de novo diffuse large B-cell lymphomas (DLBCL) that show a CD20 immunohistochemistry (IHC)-positive and flow cytometry (FCM)- negative (IHC [+]/FCM [−]) phenotype.

2012年6月29日 · In patients treated with retuximab (a humanized anti-CD20 antibody) for malignant B-cell lymphoma, the CD20 epitopes disappear (both in normal and neoplastic B-cells) as a result of down-modulation of CD20 m-RNA in the cells.

Identifying specific protein markers using IHC, such as CD3 for T-cell lymphomas or CD20 for B-cell lymphomas, allows for accurate diagnosis and classification, guiding appropriate treatment strategies.

2009年4月16日 · We determined the association between CD20 expression and clinical outcome in patients with diffuse large B-cell lymphoma (DLBCL). The mean fluorescence intensity of CD20 and CD19 was determined by FCM, and the cytoplasmic expression of CD20 was determined by immunohistochemistry (IHC) on 272 diagnostic DLBCL samples.

2025年3月20日 · IHC is commonly used to confirm B cell lineage in lymphomas, with staining intensity providing insights into tumor heterogeneity. Unlike flow cytometry, IHC preserves tissue architecture, enabling assessment of CD20 distribution within the tumor microenvironment. Western blotting is another method, particularly in research settings.