In this issue of Immunity, Weulersse et al. and Braun et al. explain how CD226 expression loss on CD8+ T cell impairs TCR-driven activation, and thereby anti-tumor effector responses, tantamount to taking the CD8+ T cell’s foot off the gas pedal.

2021年1月8日 · CD226 expression on CD8 + T cells is downregulated in the tumor microenvironment via both an Eomes-dependent transcriptional mechanism and a CD155-mediated posttranslational mechanism, leading...

HIV-specific CD8 + T cells were almost exclusively TIGIT+, and HIV-specific TIGIT hi cells were negatively correlated with polyfunctionality and displayed a diminished expression of CD226 (Tauriainen et al., 2017). All these highlight the important role of TIGIT/CD226 axis in viral infections and suggest a potential new avenue for the ...

2022年4月29日 · cd226是一种共刺激受体，广泛表达于免疫细胞，包括t细胞、nk细胞、单核细胞等，以及血小板。tigit以比cd226更高的亲和力结合cd155，从而限制cd226介导的激活。另外，tigit还直接在细胞上顺式结合cd226，破坏其与cd155的同源二聚体的结合能力。

尽管研究不多， CD226 是一种受TIGIT调控的共刺激受体，在抗肿瘤CD8+T细胞应答中具有多方面的功能，在小鼠肿瘤模型中，CD226在调节抗肿瘤反应中的重要性得到了证实，使用CD226中和性单克隆抗体 (mAb)可消除抗PD-L1和抗TIGIT抗体联用的效力。 此外，CD226表达减少或缺失的CD8+T细胞表现出功能障碍的特征，这些细胞存在于肿瘤中，并与肿瘤免疫治疗耐药性相关。 研究发现同时使用抗PD-1和抗TIGIT抗体可以达到很好的协同抗肿瘤效果，但是具体的分子机制还 …

2023年3月28日 · It is well-known that CD226 serves as a critical activating receptor on various immune cells, such as lymphocytes and monocytes, and it is suggested to promote anti-tumor immunity in the tumor microenvironment (TME). Herein, we showed a crucial regulatory role of CD226 in CD8 + T cell-mediated anti-tumor response in TME of human gastric cancer ...

2023年1月30日 · CD226 has been reported to participate in the rescue of CD8 + T cell dysfunction. In this study, we aimed to assess the prognostic value of CD226 in tumor-infiltrating lymphocytes (TILs)...

众所周知，CD226 是淋巴细胞和单核细胞等多种免疫细胞的关键激活受体，可在肿瘤微环境 (TME) 中促进抗肿瘤免疫。 在此，我们展示了 CD226 在 CD8 中的关键调节作用 + 人胃癌 (GC) TME 中 T 细胞介导的抗肿瘤反应。 具体而言，癌组织中 CD226 表达的增加与 GC 患者更好的临床结果显着相关。 此外，增加的浸润性 CD226 + CD8 + T细胞和浸润性CD226比例增加 + CD8 + CD8中的T细胞 + 癌组织内的 T 亚群也可能是 GC 患者有价值的预后预测因子。 从机械上讲，使用测 …

CD226 loss limits the efficacy of immune checkpoint blockade and CD137 agonists. CD8 + T cells within the tumor microenvironment (TME) are exposed to various signals that ultimately determine functional outcomes. Here, we examined the role of the co-activating receptor CD226 (DNAM-1) in CD8 + T cell function.

Herein, we showed a crucial regulatory role of CD226 in CD8 + T cell-mediated anti-tumor response in TME of human gastric cancer (GC). Specifically, the increased CD226 expression in cancer tissues was significantly associated with better clinical outcomes in GC patients.