CD244 (Cluster of Differentiation 244) also known as 2B4 or SLAMF4 is a protein that in humans is encoded by the CD244 gene. [5] CD244 is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule family of receptors (SLAMF) which are expressed in different types of hematopoietic cells. [6]

2024年12月24日 · CD244 (CD244 Molecule) is a Protein Coding gene. Diseases associated with CD244 include Rheumatoid Arthritis and Tuberculosis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Genes associated with the …

2024年3月18日 · 该研究强调了 CD244 在抑制 黑色素瘤 中抗肿瘤巨噬细胞生成和肿瘤 抗原特异性T细胞 反应中对单核细胞/巨噬细胞的新作用。 研究结果表明，CD244缺陷的巨噬细胞有可能与 免疫检查点抑制剂 联合用作治疗剂。 此外，CD244 在单核细胞谱系细胞中的表达可作为癌症患者的 …

2021年3月24日 · CD244 is a cell surface protein expressed by NK cells, T cells, monocytes, eosinophils, myeloid-derived suppressor cells, and dendritic cells. CD244 binds to the ligand CD48 on adjacent cells and transmits stimulatory or …

2021年3月23日 · CD244 is on the surfaces of various immune cells in the tumor microenvironment, and it helps to regulate immune function, and plays an essential role in tumor onset and development. Moreover, CD244 can be used as a diagnostic and prognostic marker, and may be useful for the immunotherapeutic treatment of tumors . This review describes the ...

2b4 (cd244)是信号通路淋巴细胞活化分子相关受体家族中的一种细胞表面糖蛋白，在所有nk细胞、cd8+ t细胞和树突状细胞上均有表达，参与nk细胞和t细胞功能的调节。

cd244 分子： 该基因编码一种在自然杀伤 (nk) 细胞 (和一些 t 细胞) 上表达的细胞表面受体，该受体介导非主要组织相容性复合体 (mhc) 限制性杀伤。 NK 细胞和靶细胞之间通过该受体的相互作用被认为可以调节 NK 细胞的细胞溶解活性。

2025年2月8日 · CD244 represents a new therapeutic target in head and neck squamous cell carcinoma. Increased attrition of memory T cells during sepsis requires 2B4. The Emerging Role of CD244 Signaling in Immune Cells of the Tumor Microenvironment.

CD244 is a cell surface protein expressed by NK cells, T cells, monocytes, eosinophils, myeloid-derived suppressor cells, and dendritic cells. CD244 binds to the ligand CD48 on adjacent cells and transmits stimulatory or inhibitory signals that regulate immune function.

免疫受体CD244是信号淋巴细胞活化分子家族成员,在NK细胞、T细胞、嗜酸性粒细胞的活性调节中具有重要的作用,在感染免疫、炎症发生和肿瘤免疫中也发挥重要的调节作用,因而研究CD244的分子结构、免疫调节作用及其机制对感染和肿瘤的免疫治疗具有重要的意义。 引用本文: 杨秉芬, 程小星. CD244免疫调节作用及其机制的研究进展 [J] . 国际免疫学杂志,2012,35 ( 05 ): 362-366. DOI: 10.3760/cma.j.issn.1673-4394.2012.05.009.