Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (Inducible T-cell COStimulator) gene. [5] [6] [7] [8] [9] The protein belongs to the CD28 and CTLA-4 cell-surface receptor family. These are proteins expressed on the surface of immune cells that mediate signalling between them.

2024年8月22日 · 诱导性t细胞共刺激因子（icos，cd278）是一种激活性共刺激免疫检查点，在活化的t细胞上表达。可诱导t细胞的增殖、存活和分化，并调节多种t细胞功能。icos可作为预测和监测t细胞介导的免疫治疗反应的生物标志物。

Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including …

Inducible T-cell co-stimulator (ICOS, CD278) is a member of CD28 family, which is induced after TCR and/or CD28 co-stimulation and promotes T cell activation and proliferation. The ligand of ICOS, ICOSL, is expressed on APCs including macrophages, DCs and B cells, and can be induced in nonlymphoid tissues under inflammatory conditions [ 188 ].

cd278. icos. 激活的 t 细胞。 增强 t 细胞对外来抗原的所有基础应答，包括增殖、分泌淋巴因子、促进介导细胞间相互作用的分子的表达以及促进 b 细胞分泌抗体。 cd279. pd-1. 激活的 t 细胞和 b 细胞。 参与 t 细胞耐受的抑制性细胞表面受体。 cd280. mrc2

ICOS/CD278 分子靶点信息概述. 分子名：ICOS, inducible T cell costimulator; 别名：AILIM; CD278; 全称：inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; ICOS/CD278 分子靶点综述. CD278属于CD28和CTLA-4细胞表面受体家族，在活化的T细胞中高度表达。

icos与肿瘤免疫 icos（又称cd278）最早于1999年被科学家发现，它是一种在激活的t细胞上表达的免疫检查点，是共刺激受体的一种，与ctla-4、pd-1等同为cd28家族成员。

2020年7月6日 · CD278)/ target=_blank class=infotextkey>ICOS（又称CD278）最早于1999年被科学家发现，它是一种在激活的T细胞上表达的免疫检查点，是共刺激受体的一种，与CTLA-4、PD-1等同为CD28家族成员。

Inducible T cell costimulator (ICOS, cluster of differentiation (CD278)) is an activating costimulatory immune checkpoint expressed on activated T cells. Its ligand, ICOSL is expressed on antigen-presenting cells and somatic cells, including tumour cells in the tumour microenvironment.

2023年2月28日 · Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including tumor cells in the tumor microenvironment) [16, 17].