肿瘤免疫靶点 | CD28 - 知乎 - 知乎专栏
2024年10月9日 · CD28主要作为“第二信号” （与靶细胞表面的B7-1/ B7-2结合） 降. B7配体家族和CD28受体家族成员之间的相互作用提供了T细胞的共刺激或共抑制作用，调节T细胞的活化和耐受性，对于对外来病原体产生的免疫反应和适当终止免疫反应以防止炎症诱导的组织损伤至关重要。 一般将B7-CD28共…
B7 (protein) - Wikipedia
B7 is a type of integral membrane protein found on activated antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity of a MHC-TCR signal between the APC and the T cell, respectively.
CD28 - 百度百科
cd28是t淋巴细胞表面表达的共刺激分子，对t细胞的活化起到重要作用。 它与APC（抗原递呈细胞）上的B7分子结合，介导T细胞的共刺激并促进其存活、增殖以及产生细胞因子。
【靶点聚焦】B7-CD28超家族：T细胞活化与增殖的“开关”_ACROBi…
B7-1/B7-2是最早发现的两个B7家族成员，受体CTLA-4和CD28与二者互作，调控T细胞状态，进而调节机体免疫。 但是B7-2和CD28表现为正调节信号，B7-1表现为负调节信号。 百时美施贵宝的2款融合蛋白药物已经批准上市，辉瑞、康宁杰瑞均有此靶点研发布局。 B7-H1即为我们熟知的PD-L1, PD1/PD-L1是经典的协同抑制信号途径，目前批准上市的药物更是百花齐放，罗氏Tecentriq 阿特珠单抗是 FDA批准的第一个PD-L1药物，获批的药物还有默克/辉瑞的Bavencio、阿斯利康 …
人人学懂免疫学：第二十一期|CD28|免疫学|信号|分子|激活|刺激
2021年3月24日 · 在本期推送中，我们介绍了B7与T细胞上的CD28结合产生阳性的激活信号，激活T细胞，增强免疫应答；B7与CTLA-4结合时产生阴性信号，抑制T细胞的活化，下调免疫反应。 注：图片来源于参考书及网络。 文章无商业用途，仅用来传递知识，如有版权问题，联系删除。 如因版权等有疑问，请于本文刊发30日内联系药学速览。 原创内容未经授权，禁止转载至其他平台。 有问题可发邮件至[email protected]获取更多信息。 ©2020 药学速览 保留所有权利.
The B7–CD28 superfamily - Nature Reviews Immunology
2002年2月1日 · New B7 and CD28 family members and new pathways have recently been identified that seem to be especially important for regulating the responses of previously activated, rather than...
The B7:CD28 family and friends: Unraveling coinhibitory interactions
2024年2月13日 · In this review, Sharpe and colleagues review inhibitory members of the B7-CD28 family and their roles in regulating immune responses with an emphasis on CTLA-4, PD-1, and the increasingly complex network of cis and trans interactions with their ligands in lymphoid organs and the periphery with implications for infection, autoimmunity, and anti ...
Recent advancements in the B7/CD28 immune checkpoint …
2023年4月17日 · The B7/CD28 families of immune checkpoints play vital roles in negatively or positively regulating immune cells in homeostasis and various diseases.
The B7:CD28 family and friends: Unraveling coinhibitory interactions
2024年2月13日 · Costimulatory pathways within the B7:CD28 family provide essential signals for optimal T cell activation and clonal expansion. They provide crucial inhibitory signals that maintain immune homeostasis, control resolution of inflammation, regulate host defense, and promote tolerance to prevent autoimmunity.
Considering B7-CD28 as a family through sequence and structure
The B7-CD28 family is comprised of such immune-regulatory receptors, and antibodies against its members programmed cell death protein 1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) have revolutionized cancer treatment. These therapies promote an immune response against tumor cells, which ...
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