2014年3月2日 · Nature Immunology - The transcription factor BATF is required for differentiation of certain helper T cell subsets. Haining and colleagues show that BATF crucially regulates CD8+ effector cells...

2011年9月6日 · We found that loss of basic leucine zipper transcription factor, ATF-like (BATF) inhibited effector CD8 T-cell differentiation. At the late effector stage, BATF was induced by IL-12 and required for IL-12–mediated histone acetylation and survival of effector T cells.

2022年2月18日 · Naive CD8 + T cells were isolated from WT and Batf KO P14 splenocytes, stimulated with plate bound anti-CD3 (BD Biosciences, clone 145-2C11) and soluble anti-CD28 (BD Biosciences, clone 37.51) in the presence of human recombinant IL-2 (100 U/ml).

2011年5月18日 · Failure to develop GCs and antibodies of switched isotypes has been reported for many mouse strains deficient in a variety of molecules involved in interactions between T cells and B cells (such as...

2024年1月31日 · Flow cytometry analysis showed that the expression of BATF in activated CD8 + T cells was significantly higher than in CD8 + T cells without α-CD3 and CD28 stimulation (Fig. 1D, p < 0.001). To understand the relationship between BATF and the function of CD8 + T cells, we examined the association between BATF expression and the secretion of the ...

2014年2月14日 · Here, we show that the interferon regulatory factor 4 (IRF4) and its cooperating binding partner B-cell-activating transcription factor (BATF) are necessary for sustained CD8 + T-cell effector...

2023年9月15日 · We found that basic leucine zipper ATF-like transcription factor (BATF), an activator protein-1 (AP-1) superfamily transcription factor (TF), is a central component of a GRN that controls the transcriptional signature of TNFR + T regs.

BATF targets included genes involved in T cell receptor (TCR) signaling (Cd28, Cd3d, Csk) as well as genes controlling the response to inflammation, such as multiple Stats, Il12rb1, Il12rb2, Il18rap, Ifngr2, Il6st, Ifnar1, Ifnar2, and Il1r1.

Mechanistically, T cell receptor (TCR)/CD28 co-stimulation enhanced expression and function of BATF, which sustained IRF4 activity to preserve Treg cell functionality. Thus, our studies reveal that BATF links Treg cell functional specification and fitness of cellular TGs to control allergic responses, and suggest that therapeutic targeting of ...

2019年10月15日 · We thereby activated PD-1/PD-Ls pathway with human PD-L1 fusion protein and downregulated BATF expression by transfection with siRNA, then we found a significant increase in IL-2 and IFN-γ secretion from culture supernatants in response to anti-CD3 and anti-CD28 stimulation.