CD28 (Cluster of Differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and survival. When T cells are stimulated through CD28 in conjunction with the T-cell receptor (TCR), it enhances the production of various interleukins, particularly IL-6.

近日， 南开大学 免疫研究所的 曹雪涛 院士团队在《Cancer Cell》（IF 48.8）杂志上发表了题为 “Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1 （抑制癌症细胞内CD28通过靶向PD-L1增强抗肿瘤免疫并克服抗PD-1耐药性 ...

CD28 ligation leads to unique epigenetic, transcriptional, and post-translational changes in T cells that cannot be recapitulated by TCR ligation alone. We discuss the function of CD28 and its ligands in both effector and regulatory T cells. CD28 is critical for regulatory T cell survival and the maintenance of immune homeostasis.

2021年7月8日 · In this issue of Cell, Casanova and colleagues examine three family members with a mutation that results in deficiency of the T cell co-stimulatory molecule CD28. These patients exhibit clinical symptoms due to human papillomavirus-2 and -4 infections, show increased levels of Epstein-Barr virus and cytomegalovirus in the blood, and respond ...

2001年12月1日 · CD28 crosslinking reduces the number of TCRs that need to be engaged, as well as the time required for T cells to interact with antigen, and enhances the magnitude of the T-cell response. On...

2024年12月12日 · CD28-deletion in cancer cells activates cDC1 and CD8 + T cell antitumor response. Intracellular CD28 binds to and stabilizes Cd274 mRNA for PD-L1 upregulation. Deciphering mechanisms for cancer immune escape may provide targets for improving immunotherapy efficacy.

CD28, a major co-stimulatory receptor, is responsible for the optimal antigen-mediated T cell activation, proliferation, and survival of T cells. CD28 − T cells exhibit reduced antigen receptor diversity, defective antigen-induced proliferation, and a shorter replicative lifespan while showing enhanced cytotoxicity and regulatory functions.

CD28 is constitutively expressed on naïve and activated CD4 and CD8 positive T cells, 8,9 while CD80 and CD86 are induced on DCs with their activation. 10–13 CD28 was first identified in the 1980s as a co-receptor that enhanced TCR-induced proliferation and promoted the differentiation of naïve CD4 + T cells. 14,15 It encodes a 44 kDa type I tra...

2018年1月29日 · Growing evidence suggests that CD8+CD28- T cells are a unique subpopulation of regulatory T cells (Tregs) that exert broad effects on directly regulating T cells, such as by inhibiting...

CD28 is a disulfide-linked homodimer constitutively expressed on the surface of T cells. Virtually all murine T cells express CD28, whereas in human T cells, nearly all CD4 + and 50% of CD8 + cells express CD28. The CD28 − subset of T cells appears to represent a population that has undergone chronic activation and can manifest suppressive ...