The CD28 Transmembrane Domain Contains an Essential …
CD28 plays a critical role in regulating immune responses both by enhancing effector T cell activation and differentiation and controlling the development and function of regulatory T …
Structural characterization of a dimerization interface in the CD28 ...
2022年6月2日 · CD28 is an essential co-stimulator in regulating immune responses. Wu et al. report NMR structures of the transmembrane domain assembly of CD28 in lipid bicelles. They …
The CD28-Transmembrane Domain Mediates Chimeric Antigen
2021年3月23日 · CARs containing a CD28-TMD, but not a CD8-TMD, formed heterodimers with the endogenous CD28 in human T cells, as shown by co-immunoprecipitation and CAR …
The CD28 Transmembrane Domain Contains an Essential ... - PubMed
2020年7月16日 · CD28 plays a critical role in regulating immune responses both by enhancing effector T cell activation and differentiation and controlling the development and function of …
CD28 hinge used in chimeric antigen receptor (CAR) T-cells
2024年8月31日 · Here, we apply biophysical methods to characterize the structure and dynamic properties of the CD28 CAR hinge (CD28H) used in an FDA-approved CD19 CAR for the …
T Cell Receptor Signaling Can Directly Enhance the Avidity of CD28 ...
2014年2月24日 · Using a micropipet adhesion frequency assay, we show that TCR signaling enhances the direct binding between CD28 and its ligand, CD80. Although CD28 is expressed …
Crystal structure of a soluble CD28-Fab complex
2005年2月6日 · The class-averaged 5.11A1 monoclonal antibody–CD28Fc electron density gave excellent matches to re-projections of the linear crystallographic complex consisting of the …
CD28 Costimulation: From Mechanism to Therapy - Cell Press
CD28 ligation leads to unique epigenetic, transcriptional, and post-translational changes in T cells that cannot be recapitulated by TCR ligation alone. We discuss the function of CD28 and its …
The homodimer interfaces of costimulatory receptors B7 and CD28 …
2023年6月28日 · We created short peptide mimetics of the homodimer interfaces of the B7 and CD28 receptors and examined their ability to attenuate B7/CD28 coligand engagement and …
(PDF) The CD28 Transmembrane Domain Contains an
2020年7月1日 · CD28 plays a critical role in regulating immune responses both by enhancing effector T cell activation and differentiation and controlling the development and function of …