2023年2月21日 · CD28 domain and the kinase FYN mediate this LCK-independent signaling. LCK-disrupted CAR-T shows increased in vivo anti-tumor efficacy—attributed to the improved …

2003年12月1日 · CD28 potently enhances T-cell receptor (TCR)-induced proliferation and differentiation of naive T cells, especially at low TCR occupancy, making it responsible for the …

2023年2月21日 · Here, we show that CAR signaling occurs in the absence of LCK. This LCK-independent signaling requires the related SFK FYN and a CD28 intracellular domain within …

The Src family protein tyrosine kinase Fyn (p59fyn) plays an important role in thymocyte development and T cell receptor (TCR) signal transduction. Fyn has been shown to associate …

CD28 domain and the kinase FYN mediate this LCK-independent signaling. LCK-disrupted CAR-T shows increased in vivo anti-tumor efficacy—attributed to the improved memory/persistence …

2001年12月1日 · CD28 crosslinking reduces the number of TCRs that need to be engaged, as well as the time required for T cells to interact with antigen, and enhances the magnitude of …

2007年10月1日 · In this study, we describe a feedback loop in T cells that influences proliferation and the generation of effector function. We show that Fyn influences the TCR:pMHC contact …

2005年12月5日 · Fyn has been shown to associate with the TCR-CD3 complex, the protein tyrosine phosphatase CD45 and several co-receptors such as CD28 which are crucial for …

1996年6月1日 · T cell responses require a nonantigen-driven cosignal provided by CD28 (and possibly other antigens), in addition to ligation of the T cell receptor ζ (TCRζ)–CD3 complex …

In this mini-review, we provide an up-to-date overview of our understanding of the signaling mechanisms that underlie CD28 function and its potential application to the modulation of …