2024年12月24日 · CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Immunodeficiency 123 With Hpv-Related Verrucosis and Classic Mycosis Fungoides. Among its related pathways are CD28 co-stimulation and Constitutive Signaling by Aberrant PI3K in Cancer.

CD28 (Cluster of Differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and survival. When T cells are stimulated through CD28 in conjunction with the T-cell receptor (TCR), it enhances the production of various interleukins, particularly IL-6.

2020年6月7日 · The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

CD28 ligation leads to unique epigenetic, transcriptional, and post-translational changes in T cells that cannot be recapitulated by TCR ligation alone. We discuss the function of CD28 and its ligands in both effector and regulatory T cells. CD28 is critical for regulatory T cell survival and the maintenance of immune homeostasis.

2025年2月8日 · CD28 gene region is associated with genetic susceptibility to celiac disease in UK families. CD28, but not CD40L, expression is indispensable for the generation of CD4+ CD25+ regulatory T-cells that suppress GVH reactivity after BMT.

CD28 is a disulfide-linked homodimer constitutively expressed on the surface of T cells. Virtually all murine T cells express CD28, whereas in human T cells, nearly all CD4 + and 50% of CD8 + cells express CD28. The CD28 − subset of T cells appears to represent a population that has undergone chronic activation and can manifest suppressive ...

2024年3月5日 · Gene type: protein coding Also known as: Tp44. See all available tests in GTR for this gene; Go to complete Gene record for CD28; Go to Variation Viewer for CD28 variants; Summary. The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development.

2024年8月16日 · FUNCTION: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. SUBUNIT: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

2016年9月14日 · Gene target information for CD28 - CD28 molecule (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2021年7月8日 · In this issue of Cell, Casanova and colleagues examine three family members with a mutation that results in deficiency of the T cell co-stimulatory molecule CD28. These patients exhibit clinical symptoms due to human papillomavirus-2 and -4 infections, show increased levels of Epstein-Barr virus and cytomegalovirus in the blood, and respond ...