2003年12月1日 · CD28 potently enhances T-cell receptor (TCR)-induced proliferation and differentiation of naive T cells, especially at low TCR occupancy, making it responsible for the signal two predicted by...

Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here we discuss the expression, structure, and biochemistry of CD28 and its ligands.

Here, we discuss recent insights into the molecular events underlying CD28-mediated co-stimulation, its impact on gene regulation, and the differential role of CD28 expression on Treg cells versus conventional CD4 + and CD8 + T-cells.

2022年8月31日 · PD-1促进的CD28去磷酸化深刻影响TCR信号体的PI3K募集，降低PI3K/AKT途径活性及其转录靶点，如Bcl-xL。 此外，SHP-2被认为不仅负责阻断CD28共刺激信号，而且还负责抑制TCR介导的ZAP70磷酸化及其与CD3ζ的关联，这些信号会导致PKCθ和ERK激活以及下游IL-2的产生和扩增。

2000年12月26日 · Here we show that, by enhancing T cell/APC close contacts, CD28 facilitates TCR signal transduction. Moreover, the signal supplied by CD28 does not lead to increased Zap-70 and Lat phosphorylation, but amplifies PLCγ1 activation and Ca 2+ response. We provide evidence that the PTK Itk controls the latter function.

2001年12月1日 · CD28 crosslinking reduces the number of TCRs that need to be engaged, as well as the time required for T cells to interact with antigen, and enhances the magnitude of the T-cell response. On...

Current evidence shows that CD28 both potentiates TCR signaling and engages a unique array of mediators (PI3K, Grb2, FLNa) in the regulation of aspects of T-cell signaling including the transcription factor NFkB.

2021年5月15日 · The costimulatory receptor CD28 synergizes with the TCR to promote IL-2 production, cell survival, and proliferation; yet the obligatory interdependence of TCR and CD28 signaling is not well understood. Upon TCR stimulation, Gads, a Grb2-family adaptor, bridges the interaction of two additional adap …

2017年10月25日 · 结合TCR方面的研究成果，牛津大学Omer Dushek研究组利用数据建模的方法模拟了TCR与CD28的信号转导网络，提出了TCR-Ca 2+ -CD28所组成的正反馈调控环路可以迅速放大T细胞信号强度，从而极大地提高T细胞的抗原响应敏感性。

2018年12月3日 · T cell activation is initiated upon ligand engagement of the T cell receptor (TCR) and costimulatory receptors. The CD28 molecule acts as a major costimulatory receptor in promoting full activation of naive T cells.