2021年5月13日 · Uses by pathologists: T cell marker (membranous staining), although CD3 is more commonly used; marker of systemic mastocytosis Positive staining - normal: Thymocytes (95%), mature peripheral T cells (almost all), NK cells (80 - 90%), mast cells Variable thymic B cells (50%), Langerhans cells Positive staining - disease:

2025年1月30日 · CD5 is a pan-T cell marker belonging to the scavenger receptor cysteine rich (SRCR) superfamily of receptors (Eur J Immunol 2016;46:1490) Used for diagnosis of lymphomas and thymic carcinoma Helps differentiate chronic lymphocytic leukemia (CLL) and mantle cell lymphoma from other types of low grade B cell non-Hodgkin lymphomas

6 天之前 · Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). CD45 is positive in nearly all cases and it is an important marker together with other B cell markers (CD20, PAX5, CD19, CD79a, CD75, OCT2 and BOB1) in differentiating classic Hodgkin lymphoma (CHL) …

Hodgkin lymphoma: ALK1 CD3 CD15 CD20 CD30 CD45 (LCA) EBER1 / 2 / LMP PAX5 Leukemia: CD3 CD34 CD68 c-kit / CD117 E-cadherin MPO NPM1 PAX5 TdT Non-Hodgkin lymphoma & myeloma: BCL6 CD3 CD5 CD10 CD15 CD20 CD23 CD30 CXCR3 kappa & lambda light chains Ki67

2023年1月17日 · CD10 in diffuse large B cell lymphoma is a marker for germinal center phenotype (also HGAL, BCL6, CD38, LMO2), generally considered a favorable prognostic factor, secondary in part to association with cell of origin classification (germinal center B cell versus activated B cell) (Mod Pathol 2005;18:1113, J Hematop 2009;2:187)

2021年8月23日 · Comment: CD20 highlights large atypical B cells within small B cell rich nodules. CD3 is positive in background small T cells with occasional CD3 positive T cell rosettes around the large atypical B cells. A PD-1 stain shows T cell rosettes encircling the large atypical B cells in the nodular areas.

2021年9月20日 · Widely used B cell marker (also CD19, CD79a, PAX5) Retained on mature B cells until plasma cell differentiation Anti-CD20 therapy (e.g., rituximab) is available for treatment of non-Hodgkin B cell lymphoma and autoimmune diseases

2024年3月19日 · Pan T cell marker Diagnosis of myeloid (granulocytic) sarcoma (J Clin Pathol 2005;58:211) Classify subtypes of T cell lymphomas and low grade B cell lymphomas Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J Surg Pathol 2002;26:76)

5 天之前 · Dendritic cell marker Mediates cellular binding of particles and immune complexes that have activated complement Also called erythrocyte complement receptor 1 (CR1), C3b and C4b receptor Pathophysiology: Binds immune complexes coated with C3b or C4b and mediates their transport to and removal by the fixed phagocyte systems of the spleen and liver

2011年1月1日 · T cell lymphomas have no distinct marker of clonality, but cells may express an abnormal immunophenotype or TCR gene rearrangement As there are only 10 V (variable) regions, a polyclonal population of cells can appear oligoclonal T cell clonality is seen in AIDS and congenital immunodeficiency syndromes, but does NOT indicate malignancy