CD30 is the target of the FDA approved therapeutic brentuximab vedotin (Adcetris). It is approved for use in: Hodgkin lymphoma (HL) (brentuximab vedotin) after failure of autologous stem cell transplant (ASCT) HL in patients who are not ASCT candidates after failure of at least 2 multiagent chemotherapy regimens

CD30, also known as BerH2, Ki1 or TNFRSF8, is a transmembrane glycoprotein receptor that belongs to the tumor necrosis factor receptor (TNFR) and was first identified in Hodgkin lymphoma cell lines but also expressed in normal activated B and T cells.

CD30 是I型跨膜蛋白,相对分子质量为120×103 ;其编码基因位于染色体1p36 ,有2种mRNA 转录本,分别为3.4 和2.3 kb 。 人类CD30分子共有595 个氨基酸残基,包括细胞内域(188个氨基酸)、跨膜域和富含半胱氨酸的胞外结构域(362 个氨基酸)三部分。 胞外部分由6个半胱氨酸重复序列组成,与其他肿瘤坏死因子受体(tumor necrosis factor receptor,TNFR)家族具有显著同源性。 在自身免疫性疾病和CD30阳性淋巴瘤中,CD30细胞外部分易被蛋白水解酶切割成相对分子质量为88×103的可 …

2021年4月20日 · cd30是肿瘤坏死因子（tnf）受体超家族成员之一，可通过激活不同的信号通路促进细胞增殖或凋亡，于1982年在用于霍奇金淋巴瘤（hl）细胞系的单克隆 ...

2017年9月8日 · The variable expression of CD30 on both normal and malignant lymphoid cells has focused research efforts on understanding the pathogenesis of CD30 upregulation, its contribution to...

CD30 was originally described as a marker of Hodgkin's and Reed-Sternberg cells in Hodgkin's lymphoma. Cloning and characterization of cDNAs encoding CD30 and its ligand (CD30L) established these proteins as members of the tumor necrosis factor receptor (TNFR) and tumor necrosis factor (TNF) superfa …

2022年12月7日 · 1、什么是cd30？ CD30于1982年被发现，是一种分布在T细胞、B细胞等免疫细胞以及多种淋巴瘤细胞膜表面的“跨膜糖蛋白”。 “跨膜糖蛋白”，顾名思义就是贯穿细胞膜两端的蛋白，一部分在细胞外、一部分在细胞内，在结构上就分为细胞外区、跨膜区和细胞内区 ...

CD30, also known as TNFRSF8 (tumor necrosis factor receptor superfamily member 8), is a protein receptor that is heavily glycosylated inside the Golgi apparatus, as well as a tumor marker that is found on the surface of specific cells in the body, …

CD30 antigen, originally identified as a cell surface marker of the malignant Hodgkin and Reed-Sternberg (HRS) cells in Hodgkin’s lymphoma by the use of the Ki-1 monoclonal antibody, is a transmembrane glycoprotein member of the tumor necrosis factor (TNF) receptor superfamily. 1 In lymphoid cells, CD30 is an activation marker inducible in ...

Cluster determinant 30 (CD30) has been recognized since the 1980s by a monoclonal antibody (Ki-1) as an epitope of a membrane protein highly expressed on Reed–Sternberg and Hodgkin’s lymphoma cells [9 – 11] and infrequently on normal blood lymphocytes.