CD32 (c luster of d ifferentiation 32), also known as FcγRII or FCGR2, is a surface receptor glycoprotein belonging to the Ig gene superfamily. [2] CD32 can be found on the surface of a variety of immune cells. [2][3] CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes. [4]

为了将病原在宿主体内清除，抗体的Fab片段和抗原特异结合后，还会利用其Fc片段和宿主的免疫细胞表面的 Fc受体 （Fc fragment receptor, FcR）结合，激活免疫细胞，活化的免疫细胞可以通过抗体介导的吞噬作用、抗体介导的细胞杀伤作用（antibody-dependent cell-mediated ...

2019年3月18日 · FcγRs have been the focus of extensive research due to their key role linking innate and humoral immunity and their implication in both inflammatory and infectious disease. Within the human FcγR family FcγRII (activatory FcγRIIa and FcγRIIc, and inhibitory FcγRIIb) are unique in their ability to signal independent of the common γ chain.

FCγ受体（FcγR）是IgG的细胞受体，包括 FCγRIII/CD16 、 FCγRII/CD32 和 FCγRI/CD64，类型和特点如表1所示。 FcγR对激发抗体依赖性细胞毒性（ADCC）、吞噬作用和免疫复合物清除具有重要作用。

Human monocyte-derived DCs (moDCs) and circulating conventional DCs coexpress activating (CD32a) and inhibitory (CD32b) isoforms of IgG Fcγ receptor (FcγR) II (CD32). The balance between these divergent receptors establishes a threshold of DC activation and enables immune complexes to mediate opposing effects on DC maturation and function.

2019年3月19日 · FcγRs have been the focus of extensive research due to their key role linking innate and humoral immunity and their implication in both inflammatory and infectious disease. Within the human FcγR family FcγRII (activatory FcγRIIa and FcγRIIc, and inhibitory FcγRIIb) are unique in their ability to signal independent of the common γ chain.

Fc gamma receptors on leucocytes (Fc gamma R) mediate binding and phagocytosis of opsonized particles. Two structurally and functionally distinct allelic polymorphisms of the Fc gamma R have been defined: the H/R131 forms of Fc gamma RIIa (CD32), and the neutrophil antigen 1 (NA1)/NA2 forms of Fc gamma RIIIb (CD16).

CD22 is a B cell–specific member of the Siglec (sialic acid–binding Ig-lectins) family of transmembrane proteins, whereas CD32 (FcɣRIIB) is a low-affinity receptor for the Fc region of antigen-aggregated IgG.

1994年1月15日 · The low affinity IgG receptor Fc gamma RII (CD32) represents the most widely distributed class of human Fc gamma R. To analyze the biologic functions of different Fc gamma RII isoforms, we stably transfected Fc gamma RIIb1, IIb1*, IIb2, IIa, and a IIa tail- mutant to the mouse IIA1.6 B lymphoma cell …

Human immunoglobulin G (IgG) Fc receptor IIa (Fc gamma RIIa; CD32) is expressed on phagocytes, triggers phagocytosis, and represents the sole Fc receptor for IgG (Fc gamma R) capable of interaction with IgG2, the main IgG subclass induced in response to bacterial capsular polysaccharides.